Department of radiology, The First Affiliated Hospital of Bengbu Medical College, Anhui Key Laboratory of Digital Medicine and Intelligent Health, Bengbu, China.
Department of Imaging Diagnosis, Medical Imaging College, Bengbu Medical College, Bengbu, China.
Acta Neurol Scand. 2021 Feb;143(2):188-194. doi: 10.1111/ane.13350. Epub 2020 Oct 13.
The fractional amplitude of low-frequency fluctuation (fALFF) method was used to identify the regional brain activity deficits of self-limited focal epilepsy with centrotemporal spikes (SLFECS) relative to normal controls (NCs).
A total of 21 SLFECS (10 females, 11 males; mean age, 8.57 ± 1.5 years) and 21 status-matched (age, sex, and education) NCs (10 females, 11 males; mean age, 8.76 ± 2.19 years) were recruited. The fALFF method was applied to identify SLFECS-related regional brain alterations. Receiver operating characteristic (ROC) curve was applied to identify the ability of these regional brain areas in distinguishing the SLFECS group from the NCs group. The relationships between the regional brain activity deficits and clinical features were evaluated by Pearson's correlation analysis.
Self-limited focal epilepsy with centrotemporal spikes was associated with widespread regional brain activity alterations, including left cuneus with higher fALFF values, and bilateral striatum, bilateral precentral gyrus, ventral and dorsal pathway of sensory area, left dorsolateral prefrontal cortex, and left Rolandic area with lower fALFF values. ROC curve revealed excellent AUC value (0.964) of these areas in distinguishing the SLFECS group from the NCs group with high degree of sensitivity (90.5%) and specificity (95.2%). Intelligence quotient score positively correlated with the fALFF value in the left striatum (r = 0.453, p = 0.039).
The fALFF parameter could be served as a potential biomarker to identify the SLFECS-related regional brain deficits in the sensorimotor cortex and their pathways, which may be the etiology of paresthesia in SLFECS.
采用低频振幅分数（fALFF）方法，识别具有中央颞区棘波的自限性局灶性癫痫（SLFECS）相对于正常对照（NCs）的区域性脑活动缺陷。
共纳入 21 例 SLFECS（10 名女性，11 名男性；平均年龄 8.57±1.5 岁）和 21 例年龄匹配（年龄、性别和教育程度）的 NCs（10 名女性，11 名男性；平均年龄 8.76±2.19 岁）。采用 fALFF 方法识别 SLFECS 相关的区域性脑改变。应用受试者工作特征（ROC）曲线识别这些区域性脑区区分 SLFECS 组和 NCs 组的能力。采用 Pearson 相关分析评估区域性脑活动缺陷与临床特征之间的关系。
具有中央颞区棘波的自限性局灶性癫痫与广泛的区域性脑活动改变有关，包括左侧楔前叶具有更高的 fALFF 值，双侧纹状体、双侧中央前回、感觉区腹侧和背侧通路、左侧背外侧前额叶皮质和左侧 Rolandic 区具有更低的 fALFF 值。ROC 曲线显示这些区域在区分 SLFECS 组和 NCs 组方面具有出色的 AUC 值（0.964），具有较高的敏感度（90.5%）和特异性（95.2%）。智商评分与左侧纹状体的 fALFF 值呈正相关（r=0.453，p=0.039）。
fALFF 参数可作为识别感觉运动皮质及其通路中与 SLFECS 相关的区域性脑缺陷的潜在生物标志物，这可能是 SLFECS 中感觉异常的病因。
