Hedayati Bobak, Juhász Margit, Chu Sherman, Mesinkovska Natasha Atanaskova
School of Medicine, University of California, Irvine, California.
Department of Dermatology, University of California, Irvine, California.
Dermatol Surg. 2020 Oct;46 Suppl 1:S8-S13. doi: 10.1097/DSS.0000000000002524.
Cryolipolysis is a popular procedure for people seeking noninvasive body contouring. As with any novel therapy, it is critical for providers to familiarize themselves with related adverse events (AEs), to provide appropriate information to patients before treatment.
To describe reported complications and AEs associated with cryolipolysis.
A systematic review was completed using the PubMed database and following search terms: "cryolipolysis" or "lipocryolysis" or "CoolSculpting." Only randomized clinical trials, prospective cohort studies, retrospective studies, case series, and case reports describing AEs related to cryolipolysis as well as studies written in English were included for review.
Fifty-three articles were included in this review. The most common AEs associated with cryolipolysis were treatment site erythema, numbness/paresthesia, bruising, and edema. More serious complications of cryolipolysis include severe/persistent pain, dysesthesia, skin hyperpigmentation, motor neuropathy, and paradoxical adipose hyperplasia.
Cryolipolysis is a safe option for patients seeking noninvasive body contouring. Most reported AEs are minimal and resolve quickly. It is important that physicians are aware of serious, irreversible AEs and are prepared to counsel patients appropriately before treatment.
冷冻溶脂术是一种深受寻求非侵入性身体塑形者欢迎的手术。与任何新疗法一样，对于医疗服务提供者而言，在治疗前熟悉相关不良事件（AE）并向患者提供适当信息至关重要。
描述已报道的与冷冻溶脂术相关的并发症和不良事件。
使用PubMed数据库并按照以下检索词完成系统评价：“冷冻溶脂术”或“脂肪冷冻分解术”或“酷塑”。仅纳入描述与冷冻溶脂术相关不良事件的随机临床试验、前瞻性队列研究、回顾性研究、病例系列和病例报告以及英文撰写的研究进行评价。
本评价纳入了53篇文章。与冷冻溶脂术相关的最常见不良事件为治疗部位红斑、麻木/感觉异常、瘀斑和水肿。冷冻溶脂术更严重的并发症包括严重/持续性疼痛、感觉障碍、皮肤色素沉着、运动神经病变和矛盾性脂肪增生。
对于寻求非侵入性身体塑形的患者而言，冷冻溶脂术是一种安全的选择。大多数已报道的不良事件轻微且可迅速缓解。医生了解严重、不可逆的不良事件并在治疗前做好为患者提供适当咨询的准备很重要。
