Pagani R, Portolés M T, Bosch M A, Díaz-Laviada I, Municio A M
Eur J Cell Biol. 1987 Apr;43(2):243-6.
The biphasic behaviour observed in endotoxin-induced shock attributed to a direct interaction of bacterial lipopolysaccharides with the cell membrane and an indirect activation of multiple homeostatic regulatory mechanisms, cannot be completely elucidated with in vivo studies. In primary cultures of adult rat hepatocytes, lipopolysaccharide from Escherichia coli 0111:B4 affects the cytochrome P450 levels directly; however, albumin and aspartate aminotransferase secretion are induced by some mediators present in the sera of animals in acute-phase shock.
内毒素诱导的休克中观察到的双相行为归因于细菌脂多糖与细胞膜的直接相互作用以及多种稳态调节机制的间接激活，体内研究无法完全阐明这种行为。在成年大鼠肝细胞原代培养中，来自大肠杆菌0111:B4的脂多糖直接影响细胞色素P450水平；然而，白蛋白和天冬氨酸转氨酶的分泌是由急性期休克动物血清中存在的一些介质诱导的。
