Ikuse Tamaki, Toda Masanori, Kashiwagi Kosuke, Maruyama Kimiko, Nagata Masumi, Tokushima Kaori, Ito Natsuki, Tokita Kazuhide, Kyodo Reiko, Hosoi Kenji, Jimbo Keisuke, Kudo Takahiro, Shimizu Toshiaki
Department of Pediatrics, Juntendo University Faculty of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan.
Microorganisms. 2020 Sep 23;8(10):1457. doi: 10.3390/microorganisms8101457.
Evidence relating to the efficacy of eradication therapy for chronic immune thrombocytopenic purpura (cITP) in childhood is inadequate. The aim of this retrospective study was to determine the efficacy of eradication therapy for platelet response in pediatric patients with cITP in our hospital, and to perform a systematic review of previous reports about pediatric patients with cITP who were positive for infection and were treated with eradication therapy. Analysis of the data of pediatric patients with cITP in our hospital and a systematic review of digital literature databases of studies in pediatric patients with cITP were performed. Data of 33 pediatric patients with cITP from our hospital records showed that the prevalence of infection and the rate of response to platelet therapy were 15% and 33.3%, respectively. Data of 706 pediatric patients from 18 previous reports showed that the prevalence of infection and rate of platelet response were 23% and 43.8%, respectively. Eradication therapy for infection in pediatric cITP patients can be expected to result in a response equivalent to that in the adult population, with fewer adverse effects than other treatments for cITP.
关于儿童慢性免疫性血小板减少性紫癜（cITP）根除治疗疗效的证据并不充分。这项回顾性研究的目的是确定我院儿科cITP患者根除治疗对血小板反应的疗效，并对先前关于感染呈阳性且接受根除治疗的儿科cITP患者的报告进行系统评价。对我院儿科cITP患者的数据进行了分析，并对儿科cITP患者研究的数字文献数据库进行了系统评价。我院记录的33例儿科cITP患者的数据显示，感染患病率和血小板治疗反应率分别为15%和33.3%。先前18份报告中706例儿科患者的数据显示，感染患病率和血小板反应率分别为23%和43.8%。预计儿科cITP患者的感染根除治疗可产生与成人相当的反应，且不良反应少于cITP的其他治疗方法。
