Molineux G, Schofield R, Hendry J H, Testa N G
Exp Hematol. 1987 Jul;15(6):676-8.
The ectopic implantation of mouse marrow to the kidney capsule offers considerable scope as an assay of the hemopoietic microenvironment. Our previous work has shown that whole-body irradiation of the graft recipient prior to implantation results in superior ossicle formation in the kidney of the host. Here we report that a range of irradiation doses over a 4-Gy threshold are equivalent with respect to conditioning the graft recipient. We also show that two distinct and separable influences affect graft growth in the irradiated recipient, namely, a local effect brought about in the irradiated kidney (and restricted to it) and secondly, a systemic effect resulting from irradiation of sites other than the kidney, which nevertheless affects ossicle growth in the shielded renal capsule.
将小鼠骨髓异位植入肾被膜，作为造血微环境的一种检测方法具有很大的应用范围。我们之前的研究表明，在植入前对移植物受体进行全身照射，可使宿主肾脏中形成更优质的小骨。在此我们报告，超过4戈瑞阈值的一系列照射剂量在对移植物受体进行预处理方面是等效的。我们还表明，有两种不同且可分离的影响因素会影响照射受体中的移植物生长，即照射肾脏产生的局部效应（且局限于此），其次是肾脏以外部位照射产生的全身效应，不过这种效应会影响受保护肾被膜中的小骨生长。
