Goodlad R A, Wright N A
Experientia. 1987 Jul 15;43(7):780-4. doi: 10.1007/BF01945355.
There is now considerable evidence implicating several peptides in the control of gastrointestinal epithelial cell proliferation and cell renewal. While some of these may act directly, many may be involved in regulating the powerful trophic effects of the intake and digestion of food on the gut epithelium. Several peptides have been associated with the regulation of intestinal cell proliferation. There is little doubt that gastrin is trophic to the stomach, but, its role in the rest of the gastrointestinal tract is debatable. Enteroglucagon has often been associated with increased intestinal epithelial proliferation, but at the moment all the evidence for this is circumstantial. The effects of peptide YY and bombesin warrant further study. The availability of recombinant epidermal growth factor (EGF) has recently enabled us to demonstrate a powerful trophic response to infused EGF throughout the gastrointestinal tract. The increasing availability of peptides will eventually allow the rigorous in vivo evaluation of the trophic role of these potentially very important peptides.
现在有大量证据表明，几种肽参与了胃肠道上皮细胞增殖和细胞更新的调控。其中一些可能直接发挥作用，而许多可能参与调节食物摄入和消化对肠道上皮的强大营养作用。几种肽已与肠道细胞增殖的调节相关。毫无疑问，胃泌素对胃具有营养作用，但其在胃肠道其他部位的作用仍存在争议。肠高血糖素常与肠道上皮增殖增加有关，但目前所有支持这一观点的证据都是间接的。肽YY和蛙皮素的作用值得进一步研究。重组表皮生长因子（EGF）的可得性最近使我们能够证明，在整个胃肠道中，注入EGF会产生强大的营养反应。肽的可得性不断增加，最终将使我们能够对这些潜在非常重要的肽的营养作用进行严格的体内评估。
