Zheng Chengkun, Wei Man, Jia Mengdie, Cao ManMan
Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, China.
Vet Sci. 2020 Sep 23;7(4):143. doi: 10.3390/vetsci7040143.
causes severe infections in both swine and humans, making it a serious threat to the swine industry and public health. Insight into the physiology and pathogenesis of undoubtedly contributes to the control of its infection. During the infection process, a wide variety of virulence factors enable to colonize, invade, and spread in the host, thus causing localized infections and/or systemic diseases. Enzymes catalyze almost all aspects of metabolism in living organisms. Numerous enzymes have been characterized in extensive detail in , and have shown to be involved in the pathogenesis and/or physiology of this pathogen. In this review, we describe the progress in the study of some representative enzymes in , such as ATPases, immunoglobulin-degrading enzymes, and eukaryote-like serine/threonine kinase and phosphatase, and we highlight the important role of various enzymes in the physiology and pathogenesis of this pathogen. The controversies about the current understanding of certain enzymes are also discussed here. Additionally, we provide suggestions about future directions in the study of enzymes in .
它会在猪和人类中引发严重感染，对养猪业和公众健康构成严重威胁。深入了解其生理学和发病机制无疑有助于控制其感染。在感染过程中，多种毒力因子使它能够在宿主体内定殖、侵入和传播，从而引发局部感染和/或全身性疾病。酶催化生物体新陈代谢的几乎所有方面。在该病原体中，许多酶已得到详细表征，并已证明它们参与了该病原体的发病机制和/或生理学过程。在本综述中，我们描述了该病原体中一些代表性酶的研究进展，如ATP酶、免疫球蛋白降解酶以及类真核丝氨酸/苏氨酸激酶和磷酸酶，并强调了各种酶在该病原体生理学和发病机制中的重要作用。本文还讨论了当前对某些酶的理解存在的争议。此外，我们提供了关于该病原体中酶研究未来方向的建议。
