了解猪链球菌的毒力：兽医、医学和经济方面的挑战。
Understanding the virulence of Streptococcus suis: A veterinary, medical, and economic challenge.
机构信息
Groupe de recherche en écologie buccale (GREB), faculté de médecine dentaire, université Laval, 2420, rue de la Terrasse, G1V 0A6 Quebec, Canada.
Groupe de recherche en écologie buccale (GREB), faculté de médecine dentaire, université Laval, 2420, rue de la Terrasse, G1V 0A6 Quebec, Canada; Centre de recherche en infectiologie porcine et avicole (CRIPA), fonds de recherche du Québec - nature et technologie (FRQNT), J2S 2M2 Saint-Hyacinthe, Quebec, Canada.
出版信息
Med Mal Infect. 2018 May;48(3):159-166. doi: 10.1016/j.medmal.2017.10.001. Epub 2017 Nov 6.
Streptococcus suis is a major swine pathogen worldwide and causes considerable economic losses in the swine industry. S. suis is also an emerging zoonotic agent, mainly in Asia. In pigs and humans, S. suis can cause septicemia, pneumonia, endocarditis, arthritis, and meningitis with irreversible sequelae. Identification and characterization of the virulence factors produced by S. suis are major advances in the understanding of the pathogenesis of S. suis infections and has therefore opened promising avenues for vaccine development against this pathogen. This literature review aimed to update the current knowledge of the virulence mechanisms of S. suis and of the vaccination strategies tested until now.
猪链球菌（Streptococcus suis）是一种全球性的主要猪病原体，给养猪业造成了巨大的经济损失。此外，它还是一种新兴的人畜共患病病原体，主要分布在亚洲。在猪和人类中，猪链球菌可引起败血病、肺炎、心内膜炎、关节炎和脑膜炎，这些病症可能会导致不可逆转的后遗症。鉴定和描述猪链球菌产生的毒力因子，是深入了解猪链球菌感染发病机制的主要进展，因此也为针对这种病原体的疫苗开发开辟了有前景的途径。本文献综述旨在更新目前对猪链球菌毒力机制以及迄今为止所测试的疫苗接种策略的认识。
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