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在体内给予[6-³H]葡萄糖和[U-¹⁴C]葡萄糖后,对经雌激素处理的雄性家鸡(Gallus domesticus)的葡萄糖动力学进行测定。

Glucose kinetics in the oestrogen-treated male chicken (Gallus domesticus), measured after administration of [6-3H]glucose and [U-14C]glucose in vivo.

作者信息

Jones C S, Manning R

出版信息

Int J Biochem. 1987;19(5):475-8. doi: 10.1016/0020-711x(87)90071-1.

DOI:10.1016/0020-711x(87)90071-1
PMID:3297845
Abstract

Male chickens (Gallus domesticus) were treated with 17 beta-oestradiol then injected with a mixture of [6-3H]glucose and [U-14C]glucose. Subsequently, blood samples were taken to determine plasma lipid levels and several parameters of glucose metabolism, including entry rate, carbon recycling, mean transit time, the total body glucose mass, the mass of the sampling pool and the rate of outflow from this pool. Oestrogen-treated birds exhibited typical hyperlipidaemia, with significantly elevated plasma levels of triacylglyerol and nonesterified fatty acids. Oestrogen administration significantly decreased the glucose entry rate, the total body glucose mass and the rate of outflow from the sampling pool.

摘要

对雄性家鸡(原鸡)用17β-雌二醇进行处理,然后注射[6-³H]葡萄糖和[U-¹⁴C]葡萄糖的混合物。随后采集血样以测定血浆脂质水平和葡萄糖代谢的几个参数,包括进入速率、碳循环、平均转运时间、全身葡萄糖总量、采样池质量以及该池的流出速率。用雌激素处理的鸡表现出典型的高脂血症,血浆中三酰甘油和非酯化脂肪酸水平显著升高。给予雌激素显著降低了葡萄糖进入速率、全身葡萄糖总量以及采样池的流出速率。

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