School of Biological Science, Seoul National University and National Creative Research Initiative Center for Hologenomics, Seoul 151-742, South Korea.
School of Biological Science, Seoul National University and National Creative Research Initiative Center for Hologenomics, Seoul 151-742, South Korea.
Curr Opin Insect Sci. 2020 Oct;41:112-119. doi: 10.1016/j.cois.2020.09.005. Epub 2020 Sep 23.
For metazoans, nutritional stressors, such as undernutrition during growth and development, results in serious outcomes, including growth impairments and organ wasting. When undernutrition is accompanied by other complications, including chronic inflammation, a more complex pathophysiology may emerge, such as environmental enteropathy. Although nutrition is one of the most important environmental factors that influences host physiology, the mechanism by which undernutrition induces host pathophysiology is not fully understood. Recently, gut microbiome was found to alleviate undernutrition-induced pathophysiology in an insect model, revealing the importance of nutrition-microbiome interactions. Here, we discussed how nutrition-microbiome interactions influence host physiology, including growth, tissue homeostasis, immunity, and behavior, by regulating the central metabolic signaling pathways with an emphasis on findings made through Drosophila, an insect model.
对于后生动物来说，营养胁迫，如生长和发育过程中的营养不良，会导致严重的后果，包括生长受损和器官消耗。当营养不良伴随着其他并发症时，包括慢性炎症，可能会出现更复杂的病理生理学，如环境肠病。尽管营养是影响宿主生理学的最重要的环境因素之一，但营养不良导致宿主病理生理学的机制尚不完全清楚。最近，肠道微生物组被发现可以减轻昆虫模型中营养不良引起的病理生理学，这揭示了营养-微生物组相互作用的重要性。在这里，我们讨论了营养-微生物组相互作用如何通过调节中央代谢信号通路来影响宿主生理学，包括生长、组织动态平衡、免疫和行为，并特别强调了通过昆虫模型果蝇得出的发现。
