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Pirfenidone increases IL-10 and improves acute pancreatitis in multiple clinically relevant murine models.吡非尼酮增加了白细胞介素-10，改善了多种临床相关的小鼠模型中的急性胰腺炎。
JCI Insight. 2022 Jan 25;7(2):e141108. doi: 10.1172/jci.insight.141108.
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Interactions between islets and regulatory immune cells in health and type 1 diabetes.胰岛与调节性免疫细胞在健康和 1 型糖尿病中的相互作用。
Diabetologia. 2021 Nov;64(11):2378-2388. doi: 10.1007/s00125-021-05565-6. Epub 2021 Sep 22.

本文引用的文献

1
Macrophage phenotypic switch orchestrates the inflammation and repair/regeneration following acute pancreatitis injury.巨噬细胞表型转换协调急性胰腺炎损伤后的炎症和修复/再生。
EBioMedicine. 2020 Aug;58:102920. doi: 10.1016/j.ebiom.2020.102920. Epub 2020 Jul 30.
2
Know Thy Enemy-Understanding the Role of Inflammation in Severe Acute Pancreatitis.知己知彼——了解炎症在重症急性胰腺炎中的作用
Gastroenterology. 2020 Jan;158(1):46-48. doi: 10.1053/j.gastro.2019.11.039. Epub 2019 Nov 23.
3
NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis.NLRP3 炎性小体调节急性胰腺炎小鼠全身炎症反应和代偿性抗炎反应综合征的发生发展。
Gastroenterology. 2020 Jan;158(1):253-269.e14. doi: 10.1053/j.gastro.2019.09.040. Epub 2019 Oct 5.
4
Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018.美国胃肠道、肝脏和胰腺疾病的负担和成本：2018 年更新。
Gastroenterology. 2019 Jan;156(1):254-272.e11. doi: 10.1053/j.gastro.2018.08.063. Epub 2018 Oct 10.
5
Monocyte and macrophage plasticity in tissue repair and regeneration.单核细胞和巨噬细胞在组织修复与再生中的可塑性。
Am J Pathol. 2015 Oct;185(10):2596-606. doi: 10.1016/j.ajpath.2015.06.001. Epub 2015 Jun 26.
6
Activated macrophages create lineage-specific microenvironments for pancreatic acinar- and β-cell regeneration in mice.活化巨噬细胞为小鼠胰腺腺泡细胞和β细胞的再生创造谱系特异性的微环境。
Gastroenterology. 2014 Nov;147(5):1106-18.e11. doi: 10.1053/j.gastro.2014.08.008. Epub 2014 Aug 14.
7
Immune cells and immune-based therapy in pancreatitis.胰腺炎中的免疫细胞与基于免疫的治疗
Immunol Res. 2014 May;58(2-3):378-86. doi: 10.1007/s12026-014-8504-5.
8
CCL2-induced migration and SOCS3-mediated activation of macrophages are involved in cerulein-induced pancreatitis in mice.CCL2 诱导的迁移和 SOCS3 介导的巨噬细胞激活参与了 Cerulein 诱导的小鼠胰腺炎。
Gastroenterology. 2012 Apr;142(4):1010-1020.e9. doi: 10.1053/j.gastro.2011.12.054. Epub 2012 Jan 13.
9
TNF-alpha-dependent regulation of acute pancreatitis severity by Ly-6C(hi) monocytes in mice.TNF-α 依赖的 Ly-6C（hi）单核细胞在小鼠急性胰腺炎严重程度中的调控作用。
J Biol Chem. 2011 Apr 15;286(15):13327-35. doi: 10.1074/jbc.M111.218388. Epub 2011 Feb 22.

Modulation of macrophage polarity for treatment of acute pancreatitis: Are we there yet?

作者信息

Sahay Preeti, Bava Ejas P, Iyer Srikanth, Dudeja Vikas

机构信息

Department of Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.

Department of Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.

出版信息

EBioMedicine. 2020 Oct;60:103002. doi: 10.1016/j.ebiom.2020.103002. Epub 2020 Sep 23.

DOI:10.1016/j.ebiom.2020.103002
PMID:32979834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7511811/
Abstract
摘要