Perelman School of Medicine at the University of Pennsylvania, Division of General Pediatrics, Children's Hospital of Philadelphia, United States.
Perelman School of Medicine at the University of Pennsylvania, Division of General Pediatrics, Children's Hospital of Philadelphia, United States; Center for Pediatric Clinical Effectiveness and PolicyLab, The Children's Hospital of Philadelphia, United States.
Child Abuse Negl. 2020 Nov;109:104714. doi: 10.1016/j.chiabu.2020.104714. Epub 2020 Sep 24.
Urinalysis, liver enzymes (LE) and lipase are used to screen for abdominal injuries in children with suspected physical abuse (SPA). However, data on the utility of urinalysis is limited.
Describe the prevalence of hematuria in evaluations for SPA. Determine test characteristics of hematuria, LE and lipase to identify kidney and other abdominal injuries among children with SPA.
Children < 7 years receiving a urinalysis during evaluation for SPA by a hospital child protection team.
Demographic, clinical, and laboratory data including presence of hematuria (blood on urine dipstick), elevated LE (> 80 U/L) and elevated lipase (> 100 U/L) were abstracted retrospectively. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for the overall study population and for patients without abdominal symptoms.
Ten percent of patients had hematuria (N = 237). Prevalence of abdominal and kidney injuries was 7 % and 1 % respectively. Of 3 patients with kidney injury, 2 had hematuria and all had elevated LE. Sensitivity (67 %) and NPV (99 %) of hematuria to detect kidney injuries were lower than LE and the same as lipase. Specificity (91 %) and PPV (8%) of hematuria to detect kidney injury were greater than LE and similar to lipase. Sensitivity of hematuria to detect any abdominal injury (50 %) was lower than LE (81 %). Sensitivity of hematuria to detect occult abdominal injury was 0 %.
Hematuria alone did not lead to detection of kidney injury. Test characteristics of hematuria were largely similar or inferior to LE and lipase.
尿液分析、肝酶(LE)和脂肪酶被用于筛查疑似躯体虐待(SPA)儿童的腹部损伤。然而,尿液分析的效用数据有限。
描述 SPA 评估中血尿的发生率。确定血尿、LE 和脂肪酶的检测特征,以识别 SPA 儿童的肾脏和其他腹部损伤。
在医院儿童保护小组对 SPA 进行评估时,接受尿液分析的<7 岁儿童。
回顾性提取人口统计学、临床和实验室数据,包括血尿(尿液试纸有血)、LE 升高(>80 U/L)和脂肪酶升高(>100 U/L)的存在。计算了总体研究人群和无腹部症状患者的敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV)。
10%的患者有血尿(N=237)。腹部和肾脏损伤的发生率分别为 7%和 1%。3 例肾损伤患者中,2 例有血尿,所有患者的 LE 均升高。血尿检测肾脏损伤的敏感性(67%)和 NPV(99%)均低于 LE,与脂肪酶相同。血尿检测肾脏损伤的特异性(91%)和 PPV(8%)均高于 LE,与脂肪酶相似。血尿检测任何腹部损伤的敏感性(50%)均低于 LE(81%)。血尿检测隐匿性腹部损伤的敏感性为 0%。
单独血尿并不能导致肾脏损伤的检出。血尿的检测特征在很大程度上与 LE 和脂肪酶相似或劣于 LE 和脂肪酶。