Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, Indiana.
Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, Indiana.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Jun;6(6):607-615. doi: 10.1016/j.bpsc.2020.07.016. Epub 2020 Aug 1.
The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in the developing central nervous system as well as playing a major role in tuning many cognitive and physiological processes. The ECS is composed of endogenous cannabinoids, cannabinoid receptors, and the enzymes responsible for the synthesis and degradation of endocannabinoids. In addition to its endogenous roles, cannabinoid receptors are the primary target of Δ-tetrahydrocannabinol, the intoxicating component of cannabis. In this review, we summarize our current understanding of the ECS. We start with a description of ECS components and their role in synaptic plasticity and neurodevelopment, and then discuss how phytocannabinoids and other exogenous compounds may perturb the ECS, emphasizing examples relevant to psychosis.
内源性大麻素系统（ECS）是一个广泛存在的神经调质网络，参与中枢神经系统的发育，并在调节许多认知和生理过程中发挥主要作用。ECS 由内源性大麻素、大麻素受体和负责内源性大麻素合成和降解的酶组成。除了其内在作用外，大麻素受体还是 Δ-四氢大麻酚的主要靶点，Δ-四氢大麻酚是大麻的致醉成分。在这篇综述中，我们总结了我们对内源性大麻素系统的理解。我们首先描述了 ECS 的组成及其在突触可塑性和神经发育中的作用，然后讨论了植物大麻素和其他外源性化合物如何扰乱 ECS，并强调了与精神病相关的例子。
