线粒体 DNA 单倍型作为癌症的遗传修饰因子。
Mitochondrial DNA Haplotypes as Genetic Modifiers of Cancer.
机构信息
Children's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Internal Medicine, Department of Biochemistry, Simmons Comprehensive Cancer Center, Division of Endocrinology, Program in Molecular Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Trends Cancer. 2020 Dec;6(12):1044-1058. doi: 10.1016/j.trecan.2020.08.004. Epub 2020 Sep 23.
Mitochondria play an essential role in cellular metabolism, generation of reactive oxygen species (ROS), and the initiation of apoptosis. These properties enable mitochondria to be crucial integrators in the pathways of tumorigenesis. An open question is to what extent variation in the mitochondrial genome (mtDNA) contributes to the biological heterogeneity observed in human tumors. In this review, we summarize our current understanding of the role of mtDNA genetics in relation to human cancers.
线粒体在细胞代谢、活性氧（ROS）的产生和细胞凋亡的启动中起着至关重要的作用。这些特性使线粒体成为肿瘤发生途径中至关重要的整合者。一个悬而未决的问题是，线粒体基因组（mtDNA）的变异在多大程度上导致了人类肿瘤中观察到的生物学异质性。在这篇综述中，我们总结了我们目前对 mtDNA 遗传学与人类癌症之间关系的认识。
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