Department of Medical Psychology, Neuropsychology and Gender Studies & Center for Neuropsychological Diagnostics and Intervention (CeNDI), Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Department of Neurology, University Medicine Greifswald, Greifswald, Germany.
Brain Behav. 2020 Dec;10(12):e01861. doi: 10.1002/brb3.1861. Epub 2020 Sep 27.
To investigate predictors of performance changes and their time course in healthy older adults.
A post hoc analysis of a RCT investigating the effect of reasoning cognitive training (ReaCT) compared to an active control group (CG) during a time course.
An online, home-based RCT including n = 4,310 healthy participants (ReaCT: n = 2,557; CG: n = 1,753) aged 50 years and older.
Multiple regression analyses were conducted to investigate predictors (age, sex, education, severity of depression, number of training sessions the participants attended, and neuropsychological baseline values) of the outcome measures grammatical reasoning, working memory, digit vigilance, verbal short-term memory, and verbal learning at 6 weeks, 3, and 6 months.
Being female and lower education predicted improvements in grammatical reasoning scores at 6 weeks and 3 months of training.
Identifying predictors for nonpharmacological interventions may help to set up a personalized medicine approach in order to prevent cognitive decline in healthy older adults.
探究健康老年人表现变化及其时间进程的预测因素。
对一项关于推理认知训练（ReaCT）与积极对照组（CG）进行比较的 RCT 进行事后分析，观察其在一段时间内的效果。
一项在线、家庭为基础的 RCT，纳入 n=4310 名年龄在 50 岁及以上的健康参与者（ReaCT：n=2557；CG：n=1753）。
采用多元回归分析，探究年龄、性别、教育程度、抑郁严重程度、参加训练课程的次数以及神经心理学基线值等预测因素对语法推理、工作记忆、数字警戒、言语短期记忆和言语学习等结果测量指标在 6 周、3 个月和 6 个月时的影响。
女性和较低的教育程度预测了语法推理能力在 6 周和 3 个月训练后的提高。
确定非药物干预的预测因素可能有助于建立一种个性化的医学方法，以预防健康老年人的认知能力下降。
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