超重/肥胖精神分裂症患者的血浆可溶性P-选择素与甘油三酯及亚硝酸盐相关。

Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia.

作者信息

Bourassa Katelynn A, Postolache Teodor T, Dagdag Aline, Fuchs Dietmar, Okusaga Olaoluwa O

机构信息

Michael E. DeBakey VA Medical Center, Houston, TX, USA.

Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA, Veterans Health Administration, Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Denver Veterans Affairs Medical Center (VAMC), Aurora, CO, USA, Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), Aurora, CO, USA, VISN 5 Capitol Health Care Network Mental Illness Research Education and Clinical Center (MIRECC), Baltimore, MD, USA.

出版信息

Pteridines. 2020 Jan;31(1):61-67. doi: 10.1515/pteridines-2020-0012. Epub 2020 May 23.

DOI:10.1515/pteridines-2020-0012

PMID:32982068

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7518413/

Abstract

BACKGROUND

Soluble P-selectin (sP-selectin) is associated with risk factors for cardiovascular disease (CVD) but this association has not been evaluated in patients with schizophrenia. This study primarily evaluated the association of sP-selectin with plasma lipids and nitrite (NO-) respectively in overweight/obese adults with schizophrenia.

METHODS

One-hundred and six patients with schizophrenia (mean age 32.9 years; 71.60% male) were recruited from a psychiatric hospital. Participants completed a structured interview and provided a fasting blood sample. Body mass index (BMI) was used to divide the sample into normal weight and overweight/obese groups. Pearson's and partial correlation coefficients (controlling for age, sex, race, education, and inflammation) were calculated to examine the association of sP-selectin with plasma lipids, and NO- in the overweight/obese patients (primary analysis), as well as in the normal weight patients and the total sample (exploratory analyses).

RESULTS

After controlling for potential confounders, sP-selectin positively correlated with triglycerides ( = 0.38, = 0.01) and NO- ( = 0.40, < 0.01) in the overweight/obese group only.

CONCLUSIONS

Future longitudinal studies should evaluate the utility of sP-selectin as a biomarker of CVD in overweight/obese adults with schizophrenia (for example, by relating sP-selectin to incidence of cardiovascular events).

摘要

背景

可溶性P选择素（sP-selectin）与心血管疾病（CVD）的危险因素相关，但这种关联尚未在精神分裂症患者中进行评估。本研究主要评估sP选择素分别与超重/肥胖精神分裂症成年患者血浆脂质和亚硝酸盐（NO-）的关联。

方法

从一家精神病医院招募了106名精神分裂症患者（平均年龄32.9岁；男性占71.60%）。参与者完成了结构化访谈并提供了空腹血样。使用体重指数（BMI）将样本分为正常体重组和超重/肥胖组。计算Pearson相关系数和偏相关系数（控制年龄、性别、种族、教育程度和炎症），以检验超重/肥胖患者（主要分析）以及正常体重患者和总样本（探索性分析）中sP选择素与血浆脂质和NO-的关联。