In-Ho Cho, Byung-Woo Kang, Yun-Jae Park, Han-Joo Lee, Sok Park, Namju Lee
J Exerc Nutrition Biochem. 2018 Sep 30;22(3):6-13. doi: 10.20463/jenb.2018.0018.
The purpose of this study was to determine whether ginseng berry extract improves blood circulation by regulating vasodilator expression in exposed to tumor necrosis factor alpha (TNF-α)-exposed endothelial cells and muscle cells.
Nitric oxide (NO) and cGMP levels in human umbilical vein endothelial cells (HUVECs) and A7r5 cells exposed to ginseng berry extract were investigated. Based on the in vitro results, healthy participants were treated with ginseng berry extract for 4 weeks and then a non-invasive vascular screening device was used to confirm the improvement of blood circulation.
When TNF-α-treated cells were exposed to the ginseng berry extract, the expression levels of endothelial nitric oxide synthase (eNOS), NO, and cGMP were recovered to almost normal levels. In addition, TNF-ɑ-induced overexpression of vascular cell adhesion molecule 1 (VCAM-1), intracellular adhesion molecule 1 (ICAM-1), e-selectin, and p-selectin was lowered by ginseng berry extract. The ginseng berry extract significantly increased ankle brachial pressure index compared to placebo (p < 0.05).
This study confirmed that the intake of ginseng berry extract improved blood circulation and therefore, its intake would be helpful for people having problems with blood circulation.
本研究旨在确定人参浆果提取物是否通过调节暴露于肿瘤坏死因子α（TNF-α）的内皮细胞和肌肉细胞中的血管舒张剂表达来改善血液循环。
研究了人参浆果提取物对人脐静脉内皮细胞（HUVECs）和A7r5细胞中一氧化氮（NO）和环磷酸鸟苷（cGMP）水平的影响。基于体外实验结果，健康参与者接受人参浆果提取物治疗4周，然后使用非侵入性血管筛查设备确认血液循环的改善情况。
当用TNF-α处理的细胞暴露于人参浆果提取物时，内皮型一氧化氮合酶（eNOS）、NO和cGMP的表达水平恢复到几乎正常水平。此外，人参浆果提取物降低了TNF-α诱导的血管细胞黏附分子1（VCAM-1）、细胞间黏附分子1（ICAM-1）、E-选择素和P-选择素的过表达。与安慰剂相比，人参浆果提取物显著提高了踝臂压力指数（p < 0.05）。
本研究证实，摄入人参浆果提取物可改善血液循环，因此，对于有血液循环问题的人来说，摄入该提取物会有所帮助。
