Al Busaidi Aisha, Shenoy Kashinatha, Panchatcharam Sathiya Murthi, Al-Mujaini Abdullah
Department of Ophthalmology, Sultan Qaboos University Hospital, Muscat, Oman.
Research Section, Oman Medical Specialty Board, Muscat, Oman.
Clin Ophthalmol. 2020 Sep 14;14:2631-2638. doi: 10.2147/OPTH.S269508. eCollection 2020.
There is some evidence suggesting a different nature of response to selective laser trabeculoplasty (SLT) among different races. Therefore, we aimed to assess the short-term efficacy, safety and nature of outcome of SLT in Omani eyes.
A retrospective review was performed of patients with open-angle glaucoma (OAG) or ocular hypertension (OHTN) who underwent a single session of 360-degree SLT between January 1, 2017 and December 31, 2018. The main outcome was mean IOP reduction and attainment of treatment success at 5 weeks and 12 weeks post treatment defined as at least 20% IOP reduction from baseline without further medications or interventions. Secondary outcomes were frequency of adverse events and factors predicting success.
A total of 33 eyes of 33 Omani patients who underwent treatment with SLT were analyzed. The nature of response to laser followed a gradual pattern as the mean IOP reduction from baseline was 20.2% (5.21 mm Hg, P <0.001) at 5 weeks and further enhanced to 27.2% (6.95 mm Hg, P <0.001) at 12 weeks. Short-term success was achieved in 51.5% and 72.2% of eyes at 5 and 12 weeks, respectively. SLT was most effective in OHTN subgroup and those with higher baseline IOP (both P <0.001). Side effects were an infrequent occurrence, minor and transient.
The short-term success of SLT in Omani eyes was clinically relevant and comparable to the gradual pattern seen in patients of Indian ancestry. It is a safe therapeutic option in selective Omani eyes.
有证据表明不同种族对选择性激光小梁成形术（SLT）的反应性质存在差异。因此，我们旨在评估SLT治疗阿曼人眼睛的短期疗效、安全性及结果性质。
对2017年1月1日至2018年12月31日期间接受单次360度SLT治疗的开角型青光眼（OAG）或高眼压症（OHTN）患者进行回顾性研究。主要结局为治疗后5周和12周时眼压平均降低情况及治疗成功与否，治疗成功定义为眼压较基线至少降低20%，且无需进一步药物治疗或干预。次要结局为不良事件发生频率及预测成功的因素。
共分析了33例接受SLT治疗的阿曼患者的33只眼睛。激光治疗后的反应性质呈逐渐变化模式，治疗后5周时眼压较基线平均降低20.2%（5.21毫米汞柱，P<0.001），12周时进一步增至27.2%（6.95毫米汞柱，P<0.001）。5周和12周时分别有51.5%和72.2%的眼睛取得短期成功。SLT在OHTN亚组及基线眼压较高的患者中最有效（均P<0.001）。副作用发生率低，程度轻微且为一过性。
SLT治疗阿曼人眼睛的短期成功具有临床意义，与印度裔患者中观察到的逐渐变化模式相当。对于部分阿曼人眼睛而言，它是一种安全的治疗选择。
