中国出现产质粒介导的RmtF和OXA-232的ST15临床分离株。
Emergence of ST15 Clinical Isolates Producing Plasmids-Mediated RmtF and OXA-232 in China.
作者信息
Shi Qingyu, Han Renru, Guo Yan, Zheng Yonggui, Yang Yang, Yin Dandan, Zhang Rong, Hu Fupin
机构信息
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People's Republic of China.
出版信息
Infect Drug Resist. 2020 Sep 11;13:3125-3129. doi: 10.2147/IDR.S257298. eCollection 2020.
BACKGROUND
RmtF, as 16S rRNA methyltransferase, leads to high-level resistance to aminoglycoside and is now barely reported.
METHODS AND RESULTS
Three -positive isolates, belonging to the pandemic clone sequence type 15, were isolated from children and coproduced and . The gene was located on an IncFIB transformable plasmid of 128,536-bp and was on a 6141-bp ColKP3 plasmid, respectively.
CONCLUSION
Plasmids with found worldwide, shared relatively low similarity, and merely matched partly in their multidrug resistance region. Notably, clinical isolates coproducing and are gradually increasing in China.
背景
RmtF作为一种16S rRNA甲基转移酶，可导致对氨基糖苷类药物产生高水平耐药性，目前鲜有报道。
方法与结果
从儿童中分离出三株属于大流行克隆序列类型15的阳性菌株，它们共同产生了 和 。 基因位于一个128,536 bp的IncFIB可转化质粒上，而 分别位于一个6141 bp的ColKP3质粒上。
结论
含有 的质粒在全球范围内均有发现，它们的相似度相对较低，且仅在其多药耐药区域部分匹配。值得注意的是，在中国，同时产生 和 的临床分离株正在逐渐增加。
Zotero 插件