关于大鼠对胍法辛或可乐定治疗撤药后血流动力学过冲反应的研究。

Studies in the rat on the haemodynamic overshoot response to withdrawal of guanfacine or clonidine treatment.

Oates H F, Stoker L M, Stokes G S

Clin Exp Pharmacol Physiol. 1979 Jan-Feb;6(1):61-8. doi: 10.1111/j.1440-1681.1979.tb00008.x.

Abstract

Normal rats were injected intramuscularly twice daily for either 3 days or 3 weeks with guanfacine (0.1 or 1.0 mg/kg), clonidine (0.01 or 0.1 mg/kg) or 0.9% saline. All were anaesthetized at various times before or after the last injection, and their arterial pressures and heart rates were monitored via a carotid artery catheter. 2. Overshoots in systolic and diastolic pressure and heart rate, reaching peak values as soon as 16 h after the last injection, occurred in all rats withdrawn from guanfacine or clonidine treatment, but in no control rats. 3. Post-withdrawal blood pressures and heart rates of rats which had received the low dose of guanfacine or clonidine were as great as those of rats which had received the ten-fold greater dosage. Moreover, withdrawal responses were as great in rats which had been treated for only 3 days as in those treated for 3 weeks. 4. The dosages and duration of treatments used in these experiments thus did not influence the magnitude of the haemodynamic overshoots provoked by withdrawal of guanfacine or clonidine. However, all groups of rats from which guanfacine was withheld exhibited significantly greater peak overshoots in systolic and diastolic pressure than did those withdrawn from clonidine treatment.

摘要

正常大鼠每日两次肌肉注射胍法辛（0.1或1.0毫克/千克）、可乐定（0.01或0.1毫克/千克）或0.9%生理盐水，持续3天或3周。在最后一次注射前或后的不同时间对所有大鼠进行麻醉，并通过颈动脉导管监测其动脉血压和心率。2. 所有停止胍法辛或可乐定治疗的大鼠均出现收缩压、舒张压和心率的过冲现象，在最后一次注射后16小时即达到峰值，而对照大鼠未出现这种情况。3. 接受低剂量胍法辛或可乐定治疗的大鼠停药后的血压和心率与接受十倍剂量治疗的大鼠一样高。此外，仅治疗3天的大鼠与治疗3周的大鼠的停药反应一样大。4. 因此，这些实验中使用的治疗剂量和持续时间并未影响因停用胍法辛或可乐定引起的血流动力学过冲的幅度。然而，所有停用胍法辛的大鼠组在收缩压和舒张压方面的峰值过冲均显著高于停用可乐定治疗的大鼠组。