胍法辛：长期治疗及撤药的影响
Guanfacine: effects of long-term treatment and withdrawal.
作者信息
Reid J L, Zamboulis C, Hamilton C A
出版信息
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):183S-188S. doi: 10.1111/j.1365-2125.1980.tb04928.x.
Abstract
- Guanfacine 3-6 mg daily lowered blood pressure in five essential hypertensives and also reduced saliva production. 2. Plasma and urinary noradrenaline values were significantly reduced throughout the 8-10 weeks of treatment. 3. On substitution of placebo tablets for guanfacine, blood pressure increased over a 2-4 d period to reach but did not significantly exceed pretreatment levels. 4. After withdrawal of guanfacine plasma noradrenaline standing was significantly higher than the pretreatment level (P < 0.05) after 4 days. Saliva production was significantly higher than the pretreatment level on day 3 and day 4 of withdrawal. 5. Guanfacine is an effective antihypertensive drug with a spectrum of actions similar to clonidine. However, in abrupt withdrawal blood pressure returned to the pretreatment level over a 2-4 d period.
摘要
- 每日服用3 - 6毫克胍法辛可降低5名原发性高血压患者的血压，并减少唾液分泌。2. 在整个8 - 10周的治疗过程中，血浆和尿去甲肾上腺素值显著降低。3. 用安慰剂片替代胍法辛后，血压在2 - 4天内升高至但未显著超过治疗前水平。4. 停用胍法辛后4天，血浆去甲肾上腺素水平显著高于治疗前水平（P < 0.05）。停药第3天和第4天唾液分泌显著高于治疗前水平。5. 胍法辛是一种有效的抗高血压药物，其作用谱与可乐定相似。然而，突然停药后，血压在2 - 4天内恢复到治疗前水平。
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