Guanfacine: effects of long-term treatment and withdrawal.
作者信息
Reid J L, Zamboulis C, Hamilton C A
出版信息
Br J Clin Pharmacol. 1980;10 Suppl 1(Suppl 1):183S-188S. doi: 10.1111/j.1365-2125.1980.tb04928.x.
Abstract
- Guanfacine 3-6 mg daily lowered blood pressure in five essential hypertensives and also reduced saliva production. 2. Plasma and urinary noradrenaline values were significantly reduced throughout the 8-10 weeks of treatment. 3. On substitution of placebo tablets for guanfacine, blood pressure increased over a 2-4 d period to reach but did not significantly exceed pretreatment levels. 4. After withdrawal of guanfacine plasma noradrenaline standing was significantly higher than the pretreatment level (P < 0.05) after 4 days. Saliva production was significantly higher than the pretreatment level on day 3 and day 4 of withdrawal. 5. Guanfacine is an effective antihypertensive drug with a spectrum of actions similar to clonidine. However, in abrupt withdrawal blood pressure returned to the pretreatment level over a 2-4 d period.
摘要
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