Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Division of Infectious Diseases, Department of Internal Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Front Immunol. 2020 Aug 28;11:2086. doi: 10.3389/fimmu.2020.02086. eCollection 2020.
Immunosuppressive therapies increase the susceptibility of patients to infections. The current pandemic with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compels clinicians to develop recommendations for successful clinical management and surveillance of immunocompromised patients at high risk for severe disease progression. With only few case studies published on SARS-CoV-2 infection in patients with rheumatic diseases, we report a 25-year-old male who developed moderate coronavirus disease 2019 (COVID-19) with fever, mild dyspnea, and no major complications despite having received high-dose prednisolone, cyclophosphamide, and rituximab for the treatment of highly active, life-threatening eosinophilic granulomatosis with polyangiitis (EGPA).
免疫抑制疗法会增加患者感染的易感性。目前严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)的大流行迫使临床医生制定建议,以成功管理和监测患有严重疾病进展高风险的免疫功能低下患者。由于仅有少数关于风湿性疾病患者 SARS-CoV-2 感染的病例研究发表,我们报告了一名 25 岁男性,他在接受高剂量泼尼松龙、环磷酰胺和利妥昔单抗治疗高度活跃、危及生命的嗜酸性肉芽肿伴多血管炎(EGPA)后,出现了中等程度的 2019 冠状病毒病(COVID-19),伴有发热、轻度呼吸困难,但没有出现重大并发症。