Byerley W F, Judd L L, Reimherr F W, Grosser B I
J Clin Psychopharmacol. 1987 Jun;7(3):127-37.
Alterations in serotonin metabolism may be an important factor in the etiology and treatment of depression. In this regard, 5-hydroxytryptophan (5-HTP), a serotonin precursor, has been given to patients with depression. Although a review of these studies suggests that 5-HTP possesses antidepressant properties, additional trials are clearly indicated. Following a discussion of the pharmacology of 5-HTP, the authors highlight adverse effects associated with its administration to depressed patients, neurologic subjects, and normal individuals. Relatively few adverse effects are associated with its use in the treatment of depressed patients.
血清素代谢的改变可能是抑郁症病因和治疗中的一个重要因素。在这方面，5-羟色氨酸（5-HTP）作为血清素的前体，已被用于治疗抑郁症患者。尽管对这些研究的综述表明5-HTP具有抗抑郁特性，但显然还需要更多试验。在讨论了5-HTP的药理学之后，作者强调了在给抑郁症患者、神经系统疾病患者和正常人使用5-HTP时的不良反应。在治疗抑郁症患者时使用5-HTP所产生的不良反应相对较少。
