Van Woert M H, Jutkowitz R, Rosenbaum D, Bowers M B
Monogr Neural Sci. 1976;3:71-80.
Biochemical studies of serotonin metabolism and a therapeutic trial of L-5-hydroxytryptophan (L-5-HTP) in combination with carbidopa were carried out in 19 patients with myoclonus. In 6 patients with intention myoclonus, the cerebrospinal fluid concentration of 5-hydroxyindoleacetic acid, a metabolite of serotonin was found to be significantly decreased. L-5-HTP with carbidopa dramatically decreased the frequency and intensity of myoclonus, particularly in those patients with a diagnosis of postanoxic intention myoclonus. The major side effects have been anorexia, nausea, vomiting, diarrhea and mental stimulation. We suggest that a deficiency of brain serotonin is causally related to myoclonic muscle movements and the therapeutic efficacy of L-5-HTP plus carbidopa may be due to the repletion of serotonin in regions of the brain where serotoninergic neurons have degenerated.
对19例肌阵挛患者进行了血清素代谢的生化研究以及L-5-羟色氨酸（L-5-HTP）联合卡比多巴的治疗试验。在6例意向性肌阵挛患者中，发现血清素代谢产物5-羟吲哚乙酸的脑脊液浓度显著降低。L-5-HTP联合卡比多巴可显著降低肌阵挛的频率和强度，尤其是在那些诊断为缺氧后意向性肌阵挛的患者中。主要副作用有厌食、恶心、呕吐、腹泻和精神兴奋。我们认为脑血清素缺乏与肌阵挛性肌肉运动有因果关系，L-5-HTP加卡比多巴的治疗效果可能是由于在血清素能神经元退化区域补充了血清素。
