Wang Zeyu, Wang Xing, Zhang Nan, Zhang Hao, Dai Ziyu, Zhang Mingyu, Feng Songshan, Cheng Quan
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Front Cell Dev Biol. 2020 Aug 26;8:795. doi: 10.3389/fcell.2020.00795. eCollection 2020.
Glioblastoma is the most malignancy tumor generated from the central nervous system along with median survival time less than 14.6 months. Pentraxin 3 has been proved its association with patients' poor survival outcome in various tumor. Recently, several studies revealed its association with glioblastoma progression but the mechanism is remained unknown. Autophagy is a programmed cells death and acts critical role in tumor progression. In this study, pentraxin 3 is recognized as prognostic prediction biomarker of glioblastoma and can promote glioblastoma progression through negative modulating tumor cells autophagy. Transcription factor JUN is assumed to participate in cells autophagy modulation by regulating pentraxin 3 expression. This work reveals novel mechanism of pentraxin 3 mediated glioblastoma progression. Furthermore, JUN is identified as potential transcription factor involves in pentraxin 3 mediated tumor cells autophagy.
胶质母细胞瘤是中枢神经系统产生的最恶性肿瘤，中位生存时间小于14.6个月。五聚体3已被证明与多种肿瘤患者的不良生存结果有关。最近，几项研究揭示了它与胶质母细胞瘤进展的关联，但其机制仍不清楚。自噬是一种程序性细胞死亡，在肿瘤进展中起关键作用。在本研究中，五聚体3被认为是胶质母细胞瘤的预后预测生物标志物，并且可以通过负向调节肿瘤细胞自噬来促进胶质母细胞瘤的进展。转录因子JUN被认为通过调节五聚体3的表达参与细胞自噬调节。这项工作揭示了五聚体3介导胶质母细胞瘤进展的新机制。此外，JUN被确定为参与五聚体3介导的肿瘤细胞自噬的潜在转录因子。
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