Dai Jiezhi, Yu Min, Chen Hua, Chai Yimin
Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Department of Vascular Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Nutr. 2020 Sep 2;7:109. doi: 10.3389/fnut.2020.00109. eCollection 2020.
Vitamin D deficiency has been associated with an increased risk in several diabetic complications. We aimed to evaluate the association between vitamin D and diabetic foot ulcer (DFU) in patients with type 2 diabetes. Fifty one patients were included in the study and divided into two groups for study of vitamin D, cholesterol, and triglycerides in blood serum on DFU. The association between vitamin D and DFU was measured by binary logistic regression analysis. The cut point of vitamin D for DFU was assessed by the receiver operating characteristic curve. Levels of 25-OH-vitamin D were lower in patients with DFU than in DM group ( < 0.0001). The AUC of 25-OH-vitamin D was 0.8254 and had an optimal cut point value (13.68 ng/ml) for the identification of DFU, with a sensitivity of 90% and a specificity of 66.67% in all patients. Multivariate logistic regression analysis indicated that the significant risk factors included 25-OH-vitamin D level ( = 0.001, OR = 0.618) and HDL-C level ( = 0.038, OR = 0.012). Low serum 25-OH-vitamin D level was associated with DFU. This indication was more specific than cholesterol and triglycerides levels.
维生素D缺乏与多种糖尿病并发症风险增加有关。我们旨在评估2型糖尿病患者中维生素D与糖尿病足溃疡（DFU）之间的关联。51名患者被纳入研究，并分为两组，以研究血清中维生素D、胆固醇和甘油三酯与DFU的关系。通过二元逻辑回归分析测量维生素D与DFU之间的关联。通过受试者工作特征曲线评估DFU的维生素D切点。DFU患者的25-羟基维生素D水平低于糖尿病组（<0.0001）。25-羟基维生素D的曲线下面积为0.8254，对于DFU的识别具有最佳切点值（13.68 ng/ml），在所有患者中的敏感性为90%，特异性为66.67%。多变量逻辑回归分析表明，显著的风险因素包括25-羟基维生素D水平（=0.001，比值比=0.618）和高密度脂蛋白胆固醇水平（=0.038，比值比=0.012）。血清25-羟基维生素D水平低与DFU有关。这一指标比胆固醇和甘油三酯水平更具特异性。
