Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Nutr Diabetes. 2019 Mar 11;9(1):8. doi: 10.1038/s41387-019-0078-9.
We aimed to evaluate the association between vitamin D deficiency and diabetic foot ulcer (DFU) in patients with diabetes. Pubmed, EMBASE, BIOSIS, the Cochrane Library, and Web of Knowledge, last updated in July 2018, were searched. We assessed eligible studies for the association between vitamin D deficiency and DFU in diabetic patients. The mean difference (MD) or the odds ratio (OR) was calculated for continuous or dichotomous data respectively. Data were analyzed by using the Cochrane Collaboration's RevMan 5.0 software. Seven studies that involved 1115 patients were included in this study. There were significantly reduced vitamin D levels in DFU (MD -13.47 nmol/L, 95%CI -16.84 to -10.10; P = 0.34, I = 12%). Severe vitamin D deficiency was significantly associated with an increased risk of DFU (OR 3.22, 95%CI 2.42-4.28; P = 0.64, I = 0%). This is the first meta-analysis demonstrating the association between serum vitamin D levels and DFU. Severe vitamin D deficiency is significantly associated with an increased risk of DFU.
我们旨在评估维生素 D 缺乏与糖尿病患者糖尿病足溃疡（DFU）之间的关联。检索了 Pubmed、EMBASE、BIOSIS、Cochrane 图书馆和 Web of Knowledge，最后更新时间为 2018 年 7 月。我们评估了合格研究中维生素 D 缺乏与糖尿病患者 DFU 之间的关联。分别对连续或二分类数据计算了均数差（MD）或比值比（OR）。使用 Cochrane 协作的 RevMan 5.0 软件进行数据分析。这项研究纳入了 7 项涉及 1115 名患者的研究。DFU 患者的维生素 D 水平明显降低（MD -13.47 nmol/L，95%CI -16.84 至 -10.10；P = 0.34，I = 12%）。严重维生素 D 缺乏与 DFU 的风险增加显著相关（OR 3.22，95%CI 2.42-4.28；P = 0.64，I = 0%）。这是首次荟萃分析表明血清维生素 D 水平与 DFU 之间存在关联。严重维生素 D 缺乏与 DFU 的风险增加显著相关。
