Chowdhury Md Riad, Chowdhury Kamrul Hasan, Hanif Nujhat Binte, Sayeed Mohammed Abu, Mouah Jannatul, Mahmud Iftekher, Kamal A T M Mostafa, Chy Md Nazim Uddin, Adnan Md
Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh.
Department of Chemistry, Wayne State University, Detroit, Michigan, 48202, United States.
Heliyon. 2020 Sep 14;6(9):e04895. doi: 10.1016/j.heliyon.2020.e04895. eCollection 2020 Sep.
(Blume), an edible wild plant, has both prospective nutraceutical and therapeutic properties. Here, we intended to explore the pharmacological potentials of the methanol extract of (MEBJ) through integrated approaches. Phytochemical screening revealed the presence of important phytoconstituents which were found to be safe during cytotoxicity analysis. The sedative potential of MEBJ (200 and 400 mg/kg) was determined by employing open field, hole cross, and thiopental sodium-induced sleeping time tests, where a significant reduction of the locomotor performance and an enhancement in the duration of sleeping have been observed, respectively. In addition, mice treated with MEBJ exhibited superior exploration during both elevated plus maze and hole board tests. In parallel, anti-diabetic potency was investigated via alpha-amylase inhibitory assay, where a dose-response increase in the percentage of inhibition has been marked. A similar response, such as an increased percentage of clot lysis, was observed during the thrombolytic test. Furthermore, molecular docking was performed with the identified compounds, demonstrated strong binding affinities to the target receptors of the experiments as mentioned above. Also, ADME/T and toxicological parameters verified the drug-like properties of the identified compounds. Collectively, these results indicate bioactivity of , which can be a potential candidate in the food and pharmaceutical industries.
(Blume),一种可食用的野生植物,具有潜在的营养保健和治疗特性。在此,我们旨在通过综合方法探索(MEBJ)甲醇提取物的药理潜力。植物化学筛选揭示了重要植物成分的存在,这些成分在细胞毒性分析中被发现是安全的。通过旷场试验、洞板试验和硫喷妥钠诱导睡眠时间试验测定了MEBJ(200和400mg/kg)的镇静潜力,分别观察到运动性能显著降低和睡眠时间延长。此外,用MEBJ处理的小鼠在高架十字迷宫试验和洞板试验中均表现出更好的探索能力。同时,通过α-淀粉酶抑制试验研究了抗糖尿病效力,其中抑制百分比呈剂量反应增加。在溶栓试验中观察到类似的反应,如凝块溶解百分比增加。此外,对鉴定出的化合物进行了分子对接,结果表明它们与上述实验的靶受体具有很强的结合亲和力。此外,ADME/T和毒理学参数验证了鉴定出的化合物的类药物特性。总体而言,这些结果表明(Blume)具有生物活性,它可能是食品和制药行业的潜在候选物。