Department of Orthopedics, Kansai Medical University, Osaka, Japan.
Department of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu-city, Shiga, 525-8577, Japan.
Sci Rep. 2020 Sep 28;10(1):15932. doi: 10.1038/s41598-020-73068-2.
Leptin and adiponectin are produced mainly in adipocytes and classified as adipocytokines because of their possible involvement in inflammation and immunity. The aim of this study was to elucidate the relationships of these adipocytokines with the disease activities of RA. We examined leptin and adiponectin concentrations and inflammatory markers such as metalloproteinase-3 (MMP-3) in 136 patients with rheumatoid arthritis (RA) (26 males and 110 females, 69.6 ± 9.3 years) and 78 controls (36 males and 42 females, 66.7 ± 15.0 years). Serum leptin and adiponectin concentrations correlated positively (r = 0.565, P < 0.001) and negatively (r = -0.331, P < 0.001) to the amount of body fat, respectively. Serum leptin and adiponectin concentrations normalized by body fat mass were significantly higher in RA than those in controls [leptin, 1.24 (median) ng/mL/kg fat in RA vs. 0.76 ng/mL/kg fat in controls; adiponectin, 0.74 μg/mL/kg fat in RA vs. 0.44 μg/mL/kg fat in controls]. Normalized adiponectin concentrations correlated positively not only to the degree of bone destruction in Steinbrocker classification but also to serum MMP-3 concentrations. Normalized leptin concentrations did not correlate to the degree of bone destruction. We conclude that adiponectin but not leptin may be involved in joint damage in RA.
瘦素和脂联素主要在脂肪细胞中产生，并因其可能参与炎症和免疫而被归类为脂肪细胞因子。本研究旨在阐明这些脂肪细胞因子与 RA 疾病活动的关系。我们检查了 136 例类风湿关节炎 (RA) 患者（26 名男性和 110 名女性，69.6±9.3 岁）和 78 名对照者（36 名男性和 42 名女性，66.7±15.0 岁）的瘦素和脂联素浓度以及炎症标志物如金属蛋白酶-3 (MMP-3)。血清瘦素和脂联素浓度分别与体脂肪量呈正相关（r=0.565，P<0.001）和负相关（r=-0.331，P<0.001）。通过体脂肪质量校正后的血清瘦素和脂联素浓度在 RA 中明显高于对照组[瘦素，1.24（中位数）ng/mL/kg 脂肪在 RA 中与 0.76 ng/mL/kg 脂肪在对照组中；脂联素，0.74 μg/mL/kg 脂肪在 RA 中与 0.44 μg/mL/kg 脂肪在对照组中]。校正后的脂联素浓度不仅与 Steinbrocker 分类的骨破坏程度呈正相关，而且与血清 MMP-3 浓度呈正相关。校正后的瘦素浓度与骨破坏程度无关。我们得出结论，脂联素而不是瘦素可能参与 RA 的关节损伤。
