Itakura T, Yokote H, Okuno T, Naka Y, Nakakita K, Kamei I, Nakai K, Imai H, Komai N
J Neurosurg. 1987 Jul;67(1):93-6. doi: 10.3171/jns.1987.67.1.0093.
The role of intracortical vasoactive intestinal polypeptide (VIP)-containing neurons in the regulation of cortical blood flow was investigated in rats by immunohistochemical and hydrogen clearance methods. Immunohistochemical studies revealed an intimate association between intracortical VIP-containing neurons and small blood vessels. Intracortical injection of a VIP solution (10(-5) M) produced significantly higher blood flow in the treated cortex (mean +/- standard error of the mean: 46.2 +/- 4.0 ml/100 gm/min) than in the untreated cortex (36.9 +/- 2.4 ml/100 gm/min). These data suggest that intracortical VIP-containing neurons produce dilatation of intracortical blood vessels.
通过免疫组织化学和氢清除法，在大鼠中研究了皮层内含有血管活性肠肽（VIP）的神经元在调节皮层血流中的作用。免疫组织化学研究显示，皮层内含有VIP的神经元与小血管之间存在密切关联。向皮层内注射VIP溶液（10^(-5) M）后，处理过的皮层血流（平均值±平均标准误差：46.2±4.0 ml/100 gm/min）显著高于未处理的皮层（36.9±2.4 ml/100 gm/min）。这些数据表明，皮层内含有VIP的神经元会引起皮层血管扩张。
