Long noncoding RNA as a novel biomarker in human cancer.

The long noncoding RNA , located in the human chromosome 9p21 region, has been reported to be involved in tumor progression. regulates gene expression via recruiting PRC2 or titrating miRNA; it also participates in signaling pathways. Evidence has indicated that is overexpressed in many cancer types and is capable of enhancing cell proliferation and cell cycle progression and inhibiting apoptosis and senescence. has the potential to serve as a biomarker for diagnosis and prognosis in cancer. In this article we focus on recent advances in studies of the oncogenic role of and its potential role in cancer medicine.