HSP10 的过表达与 HSP60 和 Mcl-1 水平相关，并可预测非小细胞肺癌患者的不良预后。
Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
出版信息
Cancer Biomark. 2021;30(1):85-94. doi: 10.3233/CBM-200410.
BACKGROUND
HSP60 and its partner HSP10 are members of heat shock proteins (HSPs) family, which help mitochondrial protein to fold correctly. Mcl-1, a member of the Bcl-2 family, plays a crucial role in regulation of cell apoptosis. Aberrant expression of HSP10, HSP60 and Mcl-1 is involved in the development of many tumors.
OBJECTIVE
To examine the association between expression of HSP10, HSP60 and Mcl-1 and clinicopathological features of non-small cell lung cancer (NSCLC).
METHODS
Tissue microarrays including 53 non-cancerous lung tissues (Non-CLT) and 354 surgically resected NSCLC were stained with anti-HSP10, anti-HSP60 and anti-Mcl-1 antibodies respectively by immunohistochemistry.
RESULTS
Higher expression of HSP10, HSP60 and Mcl-1 was found in NSCLC compared with Non-CLT. Both individual and combined HSP10 and HSP60 expression in patients with clinical stage III was higher than that in stage I ∼ II. Expression of HSP10 showed a positive correlation with HSP60 and Mcl-1. Overall survival time of NSCLC patients was remarkably shorter with elevated expression of HSP10, HSP60 and Mcl-1 alone and in combination. Moreover overexpression of HSP10 and Mcl-1 was poor independent prognostic factor for lung adenocarcinoma patients.
CONCLUSIONS
High expression of HSP10, HSP60 and Mcl-1 might act as novel biomarker of poor prognosis for NSCLC patients.
背景
热休克蛋白 60（HSP60）及其伴侣热休克蛋白 10（HSP10）是热休克蛋白（HSPs）家族的成员，有助于线粒体蛋白正确折叠。Mcl-1 是 Bcl-2 家族的一员，在细胞凋亡的调控中起着关键作用。HSP10、HSP60 和 Mcl-1 的异常表达与许多肿瘤的发生发展有关。
目的
探讨 HSP10、HSP60 和 Mcl-1 的表达与非小细胞肺癌（NSCLC）临床病理特征的关系。
方法
采用免疫组织化学方法，分别检测 53 例非癌性肺组织（Non-CLT）和 354 例手术切除的 NSCLC 组织中 HSP10、HSP60 和 Mcl-1 的表达。
结果
与 Non-CLT 相比，HSP10、HSP60 和 Mcl-1 在 NSCLC 中的表达更高。在临床分期为 III 期的患者中，HSP10 和 HSP60 的单独表达以及联合表达均高于 I～II 期。HSP10 的表达与 HSP60 和 Mcl-1 的表达呈正相关。HSP10、HSP60 和 Mcl-1 单独和联合高表达的 NSCLC 患者的总生存时间明显缩短。此外，HSP10 和 Mcl-1 的过表达是非肺腺癌患者的不良独立预后因素。
结论
HSP10、HSP60 和 Mcl-1 的高表达可能是非小细胞肺癌患者预后不良的新标志物。
Zotero 插件