Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Cancer Research Institute of Central South University, Central South University, Changsha, 410011, Hunan, China.
BMC Oral Health. 2023 Sep 3;23(1):629. doi: 10.1186/s12903-023-03311-5.
HSP60 is a heat shock proteins (HSPs) family member and help mitochondrial protein to fold correctly. Survivin is one of the inhibitors of apoptosis protein family member, which plays a significant part in cancer progression. They were capable of forming HSP60-survivin complexes and involved in the development of various tumors.
The Cancer Genome Atlas (TCGA) database demonstrated that HSP60 and survivin and their correlation on mRNA expression level with OSCC patients. Besides, expression of HSP60 and survivin proteins was studied utilizing immunohistochemistry in tissue microarrays (TMA) in OSCC and in adjacent non-cancerous squamous epithelium (Non-CCSE) tissues.
Significantly increased levels of HSP60 and survivin in most cancers compared to normal tissue by pan-cancer analysis. HSP60 and survivin proved a significantly increased expression in OSCC samples compared to Non-CCSE both on mRNA and protein (both P < 0.05). Additionally, elevated HSP60 displayed a positive correlation with survivin in terms of mRNA and protein expression levels (all P < 0.001). Patients with OSCC who had advanced clinical stage or lymph node metastasis (LNM) showed higher HSP60 expression (P = 0.004, P = 0.006, respectively). Higher levels of the proteins HSP60 and survivin were significantly inversely correlated relationship with OSCC patients' overall survival rates in multivariate survival analysis (P = 0.018, P = 0.040). From the above results, overexpression of HSP60 and survivin protein may serve as independent biomarkers predicting poor prognosis in OSCC.
Elevated HSP60 and survivin might be served as novel poor prognosis biomarkers for surgically resected OSCC patients.
HSP60 是热休克蛋白（HSPs）家族的一员，有助于线粒体蛋白正确折叠。生存素是凋亡抑制蛋白家族的一员，在癌症进展中起着重要作用。它们能够形成 HSP60-生存素复合物，并参与各种肿瘤的发生。
癌症基因组图谱（TCGA）数据库表明 HSP60 和生存素及其与口腔鳞状细胞癌（OSCC）患者 OS 相关的 mRNA 表达水平的相关性。此外，利用组织微阵列（TMA）中的免疫组织化学研究了 HSP60 和生存素蛋白在 OSCC 和相邻非癌性鳞状上皮（Non-CCSE）组织中的表达。
通过泛癌分析，与正常组织相比，大多数癌症中 HSP60 和生存素的水平显著升高。与 Non-CCSE 相比，OSCC 样本中 HSP60 和生存素的 mRNA 和蛋白表达均显著升高（均 P<0.05）。此外，HSP60 的表达与 mRNA 和蛋白表达水平呈正相关（均 P<0.001）。具有晚期临床分期或淋巴结转移（LNM）的 OSCC 患者 HSP60 表达水平较高（P=0.004，P=0.006）。在多变量生存分析中，HSP60 和生存素蛋白水平较高与 OSCC 患者的总生存率呈显著负相关（P=0.018，P=0.040）。综上所述，HSP60 和生存素蛋白的过表达可能是预测 OSCC 患者预后不良的独立标志物。
升高的 HSP60 和生存素可能是手术切除的 OSCC 患者的新型预后不良标志物。
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