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2019 年冠状病毒病疫情期间社会隔离措施对巴西婴儿急性细支气管炎住院的早期影响。

Early Impact of Social Distancing in Response to Coronavirus Disease 2019 on Hospitalizations for Acute Bronchiolitis in Infants in Brazil.

机构信息

Centro Infant, Department of Pediatrics, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Jeser Amarante Faria Children's Hospital, Joinville, Santa Catarina, Brazil.

出版信息

Clin Infect Dis. 2021 Jun 15;72(12):2071-2075. doi: 10.1093/cid/ciaa1458.

Abstract

BACKGROUND

Interventions to tackle the coronavirus disease 2019 (COVID-19) pandemic may affect the burden of other respiratory diseases. Considering the repercussions of these unique social experiences to infant health, this study aims to assess the early impact of social distancing due to the COVID-19 pandemic in hospital admissions for acute bronchiolitis.

METHODS

Data from hospitalizations of acute bronchiolitis in infants <1 year of age were obtained from the Department of Informatics of the Brazilian Public Health database for the period between 2016 and 2020. These data were also analyzed by macroregions of Brazil (North, Northeast, Southeast, South, and Midwest). To evaluate the effect of social distancing strategy on the incidence of acute bronchiolitis, the absolute and relative reductions were calculated by analyzing the yearly subsets of 2016 vs 2020, 2017 vs 2020, 2018 vs 2020, and 2019 vs 2020.

RESULTS

There was a significant reduction in all comparisons, ranging from -78% (incidence rate ratio [IRR], 0.22 [95% confidence interval {CI}, .20-.24]) in 2016 vs 2020 to -85% (IRR, 0.15 [95% CI, .13-.16]) in 2019 vs 2020, for the data from Brazil. For analyses by macroregions, the reduction varied from -58% (IRR, 0.41 [95% CI, .37-.45]) in the Midwest in 2016 vs 2020 to -93% (IRR, 0.07 [95% CI, .06-.08]) in the South in 2019 vs 2020.

CONCLUSIONS

There was a significant reduction in hospitalization for acute bronchiolitis in children <1 year old in Brazil, on the order of >70% for most analysis. Our data suggest an important impact of social distancing on reducing the transmission of viruses related to acute bronchiolitis. Such knowledge may guide strategies for prevention of viral spread.

摘要

背景

应对 2019 年冠状病毒病(COVID-19)大流行的干预措施可能会影响其他呼吸道疾病的负担。考虑到这些独特的社会经历对婴儿健康的影响,本研究旨在评估由于 COVID-19 大流行而导致的社交距离措施对急性细支气管炎住院的早期影响。

方法

从巴西公共卫生数据库的信息部门获得了 2016 年至 2020 年期间 <1 岁婴儿急性细支气管炎住院的数据。还按巴西的宏观区域(北部、东北部、东南部、南部和中西部)对这些数据进行了分析。为了评估社交距离策略对急性细支气管炎发病率的影响,通过分析 2016 年与 2020 年、2017 年与 2020 年、2018 年与 2020 年和 2019 年与 2020 年的年度子集,计算了绝对和相对减少量。

结果

所有比较均有显著减少,从 2016 年与 2020 年的 -78%(发病率比 [IRR],0.22 [95%置信区间 {CI},0.20-0.24])到 2019 年与 2020 年的 -85%(IRR,0.15 [95% CI,0.13-0.16])。对于按宏观区域进行的分析,减少幅度从 2016 年与 2020 年中西部的 -58%(IRR,0.41 [95% CI,0.37-0.45])到 2019 年与 2020 年南部的 -93%(IRR,0.07 [95% CI,0.06-0.08])不等。

结论

巴西 1 岁以下儿童急性细支气管炎住院人数显著减少,大多数分析的减少幅度超过 70%。我们的数据表明,社交距离对减少与急性细支气管炎相关的病毒传播具有重要影响。这种知识可能指导预防病毒传播的策略。

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