Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA.
NeuroDiderot, Sorbonne Paris Cité, Université Paris Diderot, Paris, Inserum, U1141, France.
Epilepsy Res. 2020 Nov;167:106454. doi: 10.1016/j.eplepsyres.2020.106454. Epub 2020 Sep 6.
The high-fat, low-carbohydrate ketogenic diet (KD) is an established treatment for drug-resistant epilepsy with a proven efficacy. The KD is being explored for Febrile Infection-Related Epilepsy Syndrome (FIRES) and epileptic encephalopathies. There is growing evidence that KD works by targeting dysregulated adaptive and innate immunity that occurs in drug-resistant epilepsy and in refractory status epilepticus. Beyond epilepsy, there are yet additional potential uses in neurological disorders because KD appears to have the broad anti-inflammatory and neuroprotective properties. The KD exerts anti-inflammatory action against a variety of experimental models of neurological disorders including multiple sclerosis, Parkinson's disease, pain, and spinal cord injury. Anti-inflammatory action of KD appears to be mediated by multiple mechanisms. Ketones bodies, caloric restriction, polyunsaturated fatty acids and gut microbiota modifications might be involved in the modulation of inflammation by the KD.
高脂肪、低碳水化合物的生酮饮食（KD）是一种已被确立的治疗耐药性癫痫的方法，其疗效已得到证实。KD 目前正在探索用于发热相关癫痫综合征（FIRES）和癫痫性脑病。越来越多的证据表明，KD 通过靶向发生在耐药性癫痫和难治性癫痫持续状态中的失调的适应性和先天免疫来发挥作用。除了癫痫之外，KD 在神经疾病中还有其他潜在的用途，因为 KD 似乎具有广泛的抗炎和神经保护特性。KD 对包括多发性硬化症、帕金森病、疼痛和脊髓损伤在内的多种神经疾病的实验模型具有抗炎作用。KD 的抗炎作用似乎是通过多种机制介导的。酮体、热量限制、多不饱和脂肪酸和肠道微生物群的改变可能参与了 KD 对炎症的调节。
