Student Research Committee, Tabriz University of Medical Sciences, Iran; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Medicine, Faculty of Cellular and Molecular Biology, University of Shiraz, Iran.
Pathol Res Pract. 2020 Oct;216(10):153226. doi: 10.1016/j.prp.2020.153226. Epub 2020 Sep 19.
Breast cancer is the most common cancer among women and its metastasis which generally observed at the last stage is the major cause of breast cancer-related death. Therefore, the agents that have the potential to prevent metastatic and invasive nature of breast cancer can open up new therapeutic strategies. Melatonin, a major hormone of pineal gland, is a powerful anti-cancer agent. There are growing evidence regarding the protective effect of melatonin against cancer invasion and metastasis. The anti-metastatic feature of melatonin accompanies with suppression of tumor proliferation, induction of tumor apoptosis, regulation of the cell cycle, modulating angiogenesis, impediment of invasion, and induction of cancer cells sensitivity to the chemotherapy agents. More recently, anti-metastatic effect of melatonin through affecting cancer stem cells and vascular mimicry has been identified. Thus, the aim of this review is to discuss the potential therapeutic effect of melatonin on breast cancer via modulating the cells invasion and metastasis.
乳腺癌是女性中最常见的癌症，其转移通常发生在晚期，是导致乳腺癌相关死亡的主要原因。因此，具有预防乳腺癌转移和侵袭特性的药物可以开辟新的治疗策略。褪黑素是松果腺的主要激素，是一种强大的抗癌剂。越来越多的证据表明褪黑素对癌症侵袭和转移具有保护作用。褪黑素的抗转移特征伴随着抑制肿瘤增殖、诱导肿瘤细胞凋亡、调节细胞周期、调节血管生成、阻碍侵袭以及诱导肿瘤细胞对化疗药物的敏感性。最近，褪黑素通过影响癌症干细胞和血管模拟来发挥抗转移作用已被确定。因此，本综述的目的是讨论通过调节细胞侵袭和转移来讨论褪黑素对乳腺癌的潜在治疗作用。
