Division of Bone & Mineral Diseases, Musculoskeletal Research Center, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Cells. 2020 Sep 24;9(10):2157. doi: 10.3390/cells9102157.
Bone infections, also known as infectious osteomyelitis, are accompanied by significant inflammation, osteolysis, and necrosis. Osteoclasts (OCs) are the bone-resorbing cells that work in concert with osteoblasts and osteocytes to properly maintain skeletal health and are well known to respond to inflammation by increasing their resorptive activity. OCs have typically been viewed merely as effectors of pathologic bone resorption, but recent evidence suggests they may play an active role in the progression of infections through direct effects on pathogens and via the immune system. This review discusses the host- and pathogen-derived factors involved in the in generation of OCs during infection, the crosstalk between OCs and immune cells, and the role of OC lineage cells in the growth and survival of pathogens, and highlights unanswered questions in the field.
骨感染，也称为感染性骨髓炎，伴随着明显的炎症、溶骨和坏死。破骨细胞 (OC) 是骨吸收细胞，与成骨细胞和骨细胞协同作用，以维持骨骼健康。众所周知，OC 会通过增加其吸收活性对炎症作出反应。OC 通常仅被视为病理性骨吸收的效应物，但最近的证据表明，它们可能通过直接作用于病原体和免疫系统，在感染的进展中发挥积极作用。本文综述了宿主和病原体来源的因素在感染过程中生成 OC 的作用、OC 与免疫细胞之间的相互作用，以及 OC 谱系细胞在病原体生长和存活中的作用，并强调了该领域尚未解决的问题。
