扩展碳离子束的线性能量传递差异对细胞杀伤和放射增敏作用的影响。

Differences in Linear Energy Transfer Affect Cell-killing and Radiosensitizing Effects of Spread-out Carbon-ion Beams.

机构信息

QST Hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

Gunma University Heavy-Ion Medical Center, Maebashi, Japan.

出版信息

Anticancer Res. 2020 Oct;40(10):5497-5502. doi: 10.21873/anticanres.14561.

DOI:10.21873/anticanres.14561

PMID:32988872

Abstract

BACKGROUND/AIM: The cell-killing and radiosensitizing effects of carbon-ion (C-ion) beams with low linear energy transfer (LET) are underexplored. We aimed to demonstrate the cell-killing effects of Co gamma rays and C-ion beams at various LET values and the radiosensitizing effect of C-ion beams at various LET and cisplatin levels.

MATERIALS AND METHODS

Human uterine cervical cancer cells were irradiated with Co gamma rays and C-ion beams at different levels of LET, with and without cisplatin treatment.

RESULTS

Low-LET C-ion beams had a superior cell-killing effect compared to Co gamma rays. Survival curves under low-LET C-ion beams were more similar to that of Co gamma rays than that of high-LET C-ion beams. Cisplatin significantly reduced cell survival after 1, 2, and 3 Gy C-ion beam irradiations at LET values of 13/30/70 keV/μm, 13/30 keV/μm, and 13 keV/μm, respectively.

CONCLUSION

Low-LET C-ion beams combined with cisplatin have higher radiosensitizing effects than high-LET C-ion beams.

摘要

背景/目的：低线性能量转移（LET）碳离子（C 离子）束的细胞杀伤和放射增敏作用尚未得到充分探索。本研究旨在展示不同 LET 值下钴伽马射线和 C 离子束的细胞杀伤效应，以及不同 LET 值和顺铂水平下 C 离子束的放射增敏效应。

材料和方法

用人子宫颈癌细胞进行照射，分别用钴伽马射线和不同 LET 值的 C 离子束进行照射，同时进行顺铂处理。

结果

低 LET 值的 C 离子束比钴伽马射线具有更好的细胞杀伤效果。低 LET 值的 C 离子束下的存活曲线比高 LET 值的 C 离子束更接近钴伽马射线。在 LET 值分别为 13/30/70 keV/μm、13/30 keV/μm 和 13 keV/μm 时，顺铂分别显著降低了 1、2 和 3 Gy C 离子束照射后的细胞存活率。