COMT rs4818、疼痛敏感度和持续时间与口腔裂隙的牙槽骨移植。
COMT rs4818, pain sensitivity and duration, and alveolar bone grafting of oral clefts.
机构信息
Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil.
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 412 Salk Pavilion, 335 Sutherland Street, Pittsburgh, PA, 15261, USA.
出版信息
Oral Maxillofac Surg. 2021 Jun;25(2):253-256. doi: 10.1007/s10006-020-00912-0. Epub 2020 Sep 29.
PURPOSE
Verifying whether the mutation in COMT rs4818 could be involved in pain modulation.
METHODS
Thirty-two individuals born with cleft lip and palate that underwent bone graft from the iliac crest bone were assessed at 12, 24, 48, 72 h, and 7 days regarding their pain experience using a visual analogic scale. DNA from each participant was collected from saliva samples, and genotyping of rs4818 was performed using TaqMan chemistry. Overrepresentation of rs4818 alleles was tested using chi-square or Fisher's exact tests with an alpha of 0.05.
RESULTS
Of the 32 individuals, eighteen reported long pain duration, nine reported high pain intensity, and fourteen low pain intensity up to 48 h. No differences were found in the distribution of individuals depending on the reported pain by sex (p = 0.12), age (p = 0.42), or cleft type (p = 0.5). The distribution of COMT r4818 alleles was different depending on the intensity and duration of pain. Carriers of the C wild-type allele were four times more likely to show high pain intensity and duration (odds ratio = 4.29, 95% confidence interval 1.13-16.18), meaning that the G variant allele is protective.
CONCLUSION
COMT rs4818 is associated with postoperative pain after alveolar bone grafting.
目的
验证 COMT rs4818 突变是否与疼痛调节有关。
方法
对 32 名因唇腭裂而行髂骨骨移植的个体，在术后 12、24、48、72 小时和 7 天，采用视觉模拟评分法评估其疼痛体验。从每位参与者的唾液样本中采集 DNA，并使用 TaqMan 化学法进行 rs4818 基因分型。采用卡方检验或 Fisher 确切概率法检验 rs4818 等位基因的过度表达，显著性水平为 0.05。
结果
在 32 名个体中，18 名报告疼痛持续时间长，9 名报告疼痛强度高，14 名报告疼痛强度低至 48 小时。根据性别（p=0.12）、年龄（p=0.42）或裂隙类型（p=0.5），报告疼痛的个体分布无差异。COMT r4818 等位基因的分布与疼痛的强度和持续时间有关。携带 C 野生型等位基因的个体发生高强度和长时间疼痛的可能性是四倍（比值比=4.29，95%置信区间 1.13-16.18），这意味着 G 变异等位基因具有保护作用。
结论
COMT rs4818 与牙槽骨移植后术后疼痛有关。
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