Sobhani Nasim C, Cassidy Arianna G, Qi Zhongxia, Yu Jingwei, Chetty Shilpa, Norton Mary E
Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA, USA.
Department of Laboratory Medicine, University of California, San Francisco, CA, USA.
Reprod Sci. 2021 Feb;28(2):570-574. doi: 10.1007/s43032-020-00330-3. Epub 2020 Sep 28.
Chromosomal abnormalities are associated with changes in complex aspects of chorionic villi histomorphology. This study used a simple scoring system to evaluate the association between atypical gross morphology and abnormal chromosomal testing on chorionic villus sampling (CVS). This retrospective cohort study included singleton pregnancies that underwent CVS at a single institution from 2006-2017. The degree of budding, branching, and vascularity (BBV) was scored from 0 to 3 for each CVS specimen, and individual scores were summed to calculate a composite BBV score. Scores were categorized into typical or atypical based on the cohort's distribution. The primary predictor was atypical BBV score, and the primary outcome was chromosomal abnormality. Fisher's exact test compared proportions, and logistic regression generated odds ratios. Among 1171 CVS specimens, 28% had chromosomal abnormalities. The chromosomally abnormal group had a higher rate of atypical BBV score than the normal group (7.3% vs 3.7%, P=0.009), a finding that remained statistically significant after controlling for maternal age, gestational age, and mode of CVS (aOR 2.2, 95% CI 1.24-3.82). Atypical chorionic villus morphology is associated with chromosomal abnormalities. This scoring system is simple, rapid, and easy to perform at the time of routine diagnosis.
染色体异常与绒毛组织形态学复杂方面的变化有关。本研究使用一种简单的评分系统来评估绒毛取样（CVS）时非典型大体形态与染色体检测异常之间的关联。这项回顾性队列研究纳入了2006年至2017年在单一机构接受CVS的单胎妊娠。对每个CVS标本的出芽、分支和血管化程度（BBV）从0到3进行评分，并将各个分数相加计算出综合BBV分数。根据队列分布将分数分为典型或非典型。主要预测因素是非典型BBV分数，主要结局是染色体异常。采用Fisher精确检验比较比例，并通过逻辑回归生成比值比。在1171个CVS标本中，28%存在染色体异常。染色体异常组的非典型BBV分数发生率高于正常组（7.3%对3.7%，P=0.009），在控制产妇年龄、孕周和CVS方式后，这一发现仍具有统计学意义（调整后比值比2.2，9�%可信区间1.24 - 3.82）。非典型绒毛形态与染色体异常有关。这种评分系统简单、快速，且在常规诊断时易于实施。
