Vis C, Everhardt E, te Velde J, Exalto N
Department of Obstetrics and Gynaecology, Spaarne Ziekenhuis, Haarlem, The Netherlands.
Hum Reprod. 1998 Oct;13(1O):2954-7. doi: 10.1093/humrep/13.10.2954.
The aim of the present study was to investigate the morphology of cytogenetically normal chorionic villi from chorionic villous sampling (CVS) specimens. This information can serve as a reference for morphological investigation of cytogenetically abnormal CVS specimens. We were also interested in any relationship between chorionic villous architecture and the outcome of pregnancy. In a reference group (n = 94, normal karyotype and ongoing pregnancies), we observed a considerable variation in villous diameter (range 116-377 microm) and vascular density (range 0.5-6.7 vessels/villus) and a high incidence of morphological criteria, classically mentioned in relation to chromosomal or other abnormalities, such as: fibrinoid deposition (74.5%), trophoblastic layer degeneration (3.2%) and abnormal proliferation (7.4%), avascular villi (54.2%), stromal oedema (55.3%), trophoblastic inclusions (23.4%) and fibrosis (23.4%). In the cytogenetic abnormal group (n = 10), neither the diameter nor the vascular density of the villi differed from the values observed in the reference group. In the reference group, we only observed a tendency for larger birthweights in relation to respectively larger and more vascularized villi. It is concluded that in CVS specimens, chorionic villous architecture and morphological criteria do not have any clinical relevance, neither do they have any important predictive value.
本研究的目的是调查绒毛取样（CVS）标本中细胞遗传学正常的绒毛膜绒毛的形态。该信息可作为细胞遗传学异常的CVS标本形态学研究的参考。我们还对绒毛膜绒毛结构与妊娠结局之间的任何关系感兴趣。在一个参照组（n = 94，核型正常且妊娠持续）中，我们观察到绒毛直径（范围为116 - 377微米）和血管密度（范围为0.5 - 6.7条血管/绒毛）有相当大的差异，以及与染色体或其他异常相关的经典提及的形态学标准的高发生率，例如：纤维素样沉积（74.5%）、滋养层退变（3.2%）和异常增殖（7.4%）、无血管绒毛（54.2%）、间质水肿（55.3%）、滋养层包涵体（23.4%）和纤维化（23.4%）。在细胞遗传学异常组（n = 10）中，绒毛的直径和血管密度均与参照组中观察到的值无差异。在参照组中，我们仅观察到出生体重分别与更大且血管化程度更高的绒毛有关的一种趋势。结论是，在CVS标本中，绒毛膜绒毛结构和形态学标准没有任何临床相关性，它们也没有任何重要的预测价值。
