Department of Biotechnology, Assam University, Silchar, Assam, 788011, India.
Department of Biomedical Science, Hallym University, Hallymdachak-gil, Chuncheon, 24252, Gangwon-do, Korea.
Biochem Genet. 2021 Feb;59(1):235-255. doi: 10.1007/s10528-020-10000-3. Epub 2020 Sep 28.
Leukemia is the outcome of aggregation of damaged white blood cells. Several genes were reported to be associated with the pathogenesis of leukemia. These genes were computationally analyzed to decipher their codon usage bias (CUB) and to identify the prime factors influencing the codon usage profile as no work was reported yet. The mean values of synonymous codon usage order (SCUO) parameter indicated low CUB of the genes. Significant positive association of SCUO with overall GC and positional GCs might signal the presence of mutational pressure. However, neutrality plot suggested the dominant role of natural selection across the genes. Along with natural selection, the role of mutation pressure was also prominent and that might be responsible for lower CUB (SCUO = 0.19) of genes. Low translational speed might permit accuracy in the process. A strong inverse relationship of translational rate was observed with CUB of genes and folding energy.
白血病是受损白细胞聚集的结果。有报道称，有几个基因与白血病的发病机制有关。这些基因被进行了计算机分析，以破译它们的密码子使用偏性（CUB），并确定影响密码子使用模式的主要因素，因为目前还没有相关工作的报道。同义密码子使用顺序（SCUO）参数的平均值表明这些基因的 CUB 较低。SCUO 与整体 GC 和位置 GC 呈显著正相关，这可能表明存在突变压力。然而，中性分析表明，自然选择在这些基因中占主导地位。除了自然选择，突变压力的作用也很突出，这可能是导致基因 CUB 较低（SCUO=0.19）的原因。较低的翻译速度可能允许在该过程中保持准确性。观察到翻译速率与基因的 CUB 和折叠能之间存在很强的负相关关系。
