Department of Urology, China Rehabilitation Research Center, Rehabilitation School of Capital Medical University, Beijing, 100068, China.
Department of Urology, Capital Medical University, Beijing, 100068, China.
Int Urol Nephrol. 2021 Mar;53(3):431-438. doi: 10.1007/s11255-020-02666-w. Epub 2020 Sep 28.
The present study investigated the inhibitory effects of a novel minimally invasive implanted tibial nerve stimulation device on non-nociceptive bladder reflexes in cats.
A wireless minimally invasive implanted nerve stimulator was implanted adjacent to the left tibial nerve in seven cats. Multiple cystometrograms (CMGs) were obtained to determine the inhibitory effects of tibial nerve stimulation (TNS) at different frequencies and intensities on the micturition reflex by infusing normal saline (NS).
TNS at 6 Hz did not significantly change the bladder capacity (BC) compared to the control level at the intensity threshold (T), while TNS significantly (P < 0.05) increased the BC to 158.89 ± 20.57% of the control level at 2 T. When stimulated at 15 Hz, TNS did not significantly (P > 0.05) change the BCs at 1 T and 2 T.
The minimally invasive implanted TNS device was shown to be effective in inhibiting the micturition reflex under physiologic conditions. Further studies are warranted to determine the inhibitory effects of TNS on nociceptive bladder reflexes.
本研究旨在探讨一种新型微创植入式胫神经刺激器对猫非伤害性膀胱反射的抑制作用。
将无线微创植入式神经刺激器植入 7 只猫的左侧胫神经旁。通过输注生理盐水（NS），获得多次膀胱测压图（CMG），以确定不同频率和强度的胫神经刺激（TNS）对排尿反射的抑制作用。
与强度阈值（T）的对照水平相比，6 Hz 的 TNS 对膀胱容量（BC）没有显著改变，而 2 T 的 TNS 则显著（P<0.05）将 BC 增加到对照水平的 158.89±20.57%。当以 15 Hz 刺激时，1 T 和 2 T 的 TNS 对 BC 没有显著影响（P>0.05）。
微创植入式 TNS 装置在生理条件下对抑制排尿反射有效。需要进一步研究以确定 TNS 对伤害性膀胱反射的抑制作用。
