Zahorec R, Hulin I, Zahorec P
Bratisl Lek Listy. 2020;121(7):466-470. doi: 10.4149/BLL_2020_077.
Coronavirus disease is caused by a virus that is the cause of a potentially fatal disease worldwide. Coronavirus is a pathogen that primarily affects the human respiratory system. Coronavirus 2019 (COVID-19) has been named WHO since February 11, 2020. The first cases of COVID-19 were reported in December 2019. In January 2020, COVID-19 infection was identified in hospitalized patients in Wuhan, China. We analyze the role of neutrophil-lymphocyte ratio (NLR) in viral infection with special emphasize on novel corona virus disease-COVID-19. NLR may be used for early detection and may reflect progression to the more severe illness leading to SARS-CoV-2. In the mini review we investigate the use of NLR as a surrogate marker for diagnosis and stratification of COVID-19.Clinical symptoms such as pneumonia, acute respiratory distress syndrome, acute heart damage have led to death. In some cases, multiple inflammations have been observed. Treatment with interferon inhalation showed no clinical effect and the condition worsened instead (Tab. 5, Fig. 1, Ref. 18). Keywords: neutrophil-to-lymphocyte ratio, corona virus SARS-CoV-2, COVID-19.
冠状病毒病是由一种在全球范围内引发潜在致命疾病的病毒引起的。冠状病毒是一种主要影响人类呼吸系统的病原体。自2020年2月11日起，新型冠状病毒2019（COVID-19）被世界卫生组织命名。2019年12月报告了首例COVID-19病例。2020年1月，在中国武汉的住院患者中发现了COVID-19感染。我们分析中性粒细胞与淋巴细胞比值（NLR）在病毒感染中的作用，特别强调新型冠状病毒病COVID-19。NLR可用于早期检测，并可能反映病情进展至更严重的疾病，导致感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。在这篇小型综述中，我们研究了NLR作为COVID-19诊断和分层替代标志物的用途。肺炎、急性呼吸窘迫综合征、急性心脏损伤等临床症状已导致死亡。在某些情况下，还观察到多种炎症。吸入干扰素治疗未显示出临床效果，病情反而恶化（表5，图1，参考文献18）。关键词：中性粒细胞与淋巴细胞比值、冠状病毒SARS-CoV-2、COVID-19 。
