Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, USA.
J Neurogenet. 2020 Sep-Dec;34(3-4):395-403. doi: 10.1080/01677063.2020.1808634. Epub 2020 Sep 29.
The last few decades have seen the structural and functional elucidation of small-molecule chemical signals called ascarosides in . Ascarosides mediate several biological processes in worms, ranging from development, to behavior. These signals are modular in their design architecture, with their building blocks derived from metabolic pathways. Behavioral responses are not only concentration dependent, but also are influenced by the current physiological state of the animal. Cellular and circuit-level analyses suggest that these signals constitute a complex communication system, employing both synergistic molecular elements and sex-specific neuronal circuits governing the response. In this review, we discuss research from multiple laboratories, including our own, that detail how these chemical signals govern several different social behaviors in We propose that the ascaroside repertoire represents a link between diverse metabolic and neurobiological life-history traits and governs the survival of in its natural environment.
过去几十年见证了小分子化学信号——叫做 ascarosides 的结构和功能的阐明。Ascarosides 在蠕虫中介导多种生物学过程，从发育到行为。这些信号在设计架构上具有模块性，其构建块源自代谢途径。行为反应不仅取决于浓度，还受到动物当前生理状态的影响。细胞和电路水平的分析表明，这些信号构成了一个复杂的通讯系统，既利用协同的分子元件，也利用性别特异性神经元回路来控制反应。在这篇综述中，我们讨论了来自多个实验室的研究，包括我们自己的研究，这些研究详细说明了这些化学信号如何在 中控制几种不同的社会行为。我们提出，ascarosides 系列代表了不同代谢和神经生物学生活史特征之间的联系，并控制了 在其自然环境中的生存。
