铜催化的 - 甲苯磺酰腙 - 含硫代氨基甲酸酯与芳基亲电试剂的 - 氨基苯并呋喃硫醚形成。
Cu-Catalyzed -Amino Benzofuranthioether Formation from -Tosylhydrazone-Bearing Thiocarbamates and Arylative Electrophiles.
机构信息
Institute of Next Generation Matter Transformation, College of Material Sciences Engineering, Huaqiao University, Xiamen, Fujian 361021, P.R. China.
Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University, College of Chemistry at Fuzhou University, Fuzhou, Fujian 350108, P.R. China.
出版信息
Org Lett. 2020 Oct 16;22(20):7874-7878. doi: 10.1021/acs.orglett.0c02778. Epub 2020 Sep 29.
An important framework of -amino benzofuranthioethers was constructed by Cu-catalyzed arylative cyclization of -tosylhydrazone-bearing thiocarbamates with silylaryl triflates or ArI. This transformation provides a novel strategy for the synthesis of valuable arylative -amino benzofuranthioethers in moderate yields which could not be obtained from known methods. The reaction features smart design, efficient construction, and mild reaction conditions.
通过 Cu 催化的 - 对甲苯磺酰基腙取代的硫代氨基甲酸酯与硅基芳基三氟甲磺酸酯或芳基碘化物的芳基化环化反应，构建了一个重要的 - 氨基苯并呋喃硫醚骨架。这种转化为中等到良好收率的有价值的芳基化 - 氨基苯并呋喃硫醚的合成提供了一种新的策略，而这些产物是无法通过已知方法获得的。该反应具有巧妙的设计、高效的构建和温和的反应条件。
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