Meher Prahallad, Samanta Raj Kumar, Manna Sourav, Murarka Sandip
Department of Chemistry, Indian Institute of Technology Jodhpur, Karwar-342037, Rajasthan, India.
Chem Commun (Camb). 2023 May 16;59(40):6092-6095. doi: 10.1039/d3cc00605k.
A photoredox-catalyzed arylative radical cascade involving -acryloyl-2-arylbenzoimidazoles and diaryliodonium triflates leading to the formation of a broad array of pharmaceutically important arylated-benzimidazo[2,1-]isoquinolin-6(5)-ones is described. Importantly, the synthesized benzimidazoisoquinolinones are amenable for further synthetic manipulation and allowed efficient access to benzimidazo-fused polycyclic heterocycles.
描述了一种光氧化还原催化的芳基化自由基级联反应，该反应涉及 -丙烯酰基-2-芳基苯并咪唑和三氟甲磺酸二芳基碘鎓盐，可生成一系列具有重要药学意义的芳基化苯并咪唑并[2,1-]异喹啉-6(5)-酮。重要的是，合成的苯并咪唑并异喹啉酮易于进行进一步的合成操作，并能有效地获得苯并咪唑稠合的多环杂环化合物。
