Collagen stimulates more platelet prostaglandin endoperoxides in thrombosis.

Platelets prostaglandin cyclic endoperoxides after collagen stimulation were measured in 7 patients with arterial thrombosis, 4 patients with recurrent deep venous thrombosis and 27 patients before undergoing total hip replacement. Patients with post-surgical D.V.T. synthetized more platelet cyclic-endoperoxides compared to those with no D.V.T. COULD BE DIVIDED INTO 2 SUBGROUPS : GROUP I with platelet cyclic endoperoxides and group II with higher cyclic-endoperoxides synthesis. Also, there was a higher ratio of platelet cyclic endoperoxides in patients with arterial thrombosis and in 2 patients with recurrent venous thrombosis and shortened platelet survival time. Thus, a greater synthesis of platelet prostaglandin cyclic, endoperoxides was formed in a number of patients with thrombosis.