前列腺素生物合成中一种中间体的形成及其与血小板释放反应的关联。
Formation of an intermediate in prostaglandin biosynthesis and its association with the platelet release reaction.
作者信息
Smith J B, Ingerman C, Kocsis J J, Silver M J
出版信息
J Clin Invest. 1974 May;53(5):1468-72. doi: 10.1172/JCI107695.
Abstract
A compound that could be converted to prostaglandin F(2alpha) by mild chemical reduction was formed by human platelets in response to arachidonic acid, collagen, or L-epinephrine. It was present in maximal amounts at about 1 min after addition of arachidonic acid or collagen to platelet-rich plasma. Its initial formation appeared to precede platelet aggregation by these agents and was closely correlated with the release of adenine nucleotides and radioactive 5-hydroxytryptamine from platelets. Moreover, the compound was itself found outside the platelets. This compound is probably an endoperoxide intermediate in prostaglandin biosynthesis and may be a trigger for the platelet release reaction.
摘要
一种可通过温和化学还原转化为前列腺素F(2α)的化合物，由人血小板在花生四烯酸、胶原或L-肾上腺素作用下形成。在向富含血小板的血浆中添加花生四烯酸或胶原后约1分钟时，其含量达到最高。这些物质最初形成似乎先于血小板聚集，并且与血小板中腺嘌呤核苷酸和放射性5-羟色胺的释放密切相关。此外，该化合物本身也存在于血小板外。这种化合物可能是前列腺素生物合成中的一种内过氧化物中间体，可能是血小板释放反应的触发因素。
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