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相似文献

1
Formation of an intermediate in prostaglandin biosynthesis and its association with the platelet release reaction.前列腺素生物合成中一种中间体的形成及其与血小板释放反应的关联。
J Clin Invest. 1974 May;53(5):1468-72. doi: 10.1172/JCI107695.
2
Effects of nitroblue tetrazolium and vitamin E on platelet ultrastructure, aggregation, and secretion.硝基蓝四氮唑和维生素E对血小板超微结构、聚集及分泌的影响。
Am J Pathol. 1977 Aug;88(2):387-402.
3
Malondialdehyde formation as an indicator of prostaglandin production by human platelets.丙二醛的形成作为人类血小板产生前列腺素的指标。
J Lab Clin Med. 1976 Jul;88(1):167-72.
4
Formation of prostaglandins during the aggregation of human blood platelets.人血小板聚集过程中前列腺素的形成。
J Clin Invest. 1973 Apr;52(4):965-9. doi: 10.1172/JCI107262.
5
Arachidonic acid-induced human platelet aggregation and prostaglandin formation.花生四烯酸诱导的人血小板聚集和前列腺素形成。
Prostaglandins. 1973 Dec;4(6):863-75. doi: 10.1016/0090-6980(73)90121-4.
6
Effect of contrast agents on platelet aggregation and 14C-serotonin release.造影剂对血小板聚集及14C-5-羟色胺释放的影响。
N Engl J Med. 1974 Jul 18;291(3):134-5. doi: 10.1056/NEJM197407182910306.
7
Conditions influencing platelet lysis.影响血小板溶解的条件。
Lab Invest. 1975 Mar;32(3):352-8.
8
The influence of prostaglandin endoperoxides on platelet ultrastructure.前列腺素内过氧化物对血小板超微结构的影响。
Am J Pathol. 1975 Aug;80(2):189-202.
9
The effect of phospholipase inhibitor mepacrine on platelet aggregation, the platelet release reaction and fibrinogen binding to the platelet surface.磷脂酶抑制剂米帕林对血小板聚集、血小板释放反应以及纤维蛋白原与血小板表面结合的影响。
Thromb Haemost. 1981 Jun 30;45(3):257-62.
10
Acetylenic analog of arachidonate that acts like aspirin on platelets.花生四烯酸的乙炔类似物，对血小板的作用类似于阿司匹林。
Science. 1974 Jan 25;183(4122):327-30. doi: 10.1126/science.183.4122.327.

引用本文的文献

1
The antiinflammatory action of some compounds with antioxidant properties.一些具有抗氧化特性的化合物的抗炎作用。
Inflammation. 1976 Dec;1(4):333-45. doi: 10.1007/BF00920335.
2
Adventures in vascular biology: a tale of two mediators.血管生物学奇遇：两种介质的故事
Philos Trans R Soc Lond B Biol Sci. 2006 May 29;361(1469):735-59. doi: 10.1098/rstb.2005.1775.
3
Thrombosis: its role and prevention in cardiovascular events--Part I. Concepts of thrombogenesis and its prevention.血栓形成：其在心血管事件中的作用及预防——第一部分。血栓形成的概念及其预防。
West J Med. 1981 Mar;134(3):234-41.
4
Effect of aspirin on platelet aggregation in diabetes mellitus.阿司匹林对糖尿病患者血小板聚集的影响。
Diabetologia. 1982 Aug;23(2):104-7. doi: 10.1007/BF01271169.
5
Eighth Gaddum Memorial Lecture. University of London Institute of Education, December 1980. Biological importance of prostacyclin.第八届加德姆纪念讲座。1980年12月于伦敦大学教育学院。前列环素的生物学重要性。
Br J Pharmacol. 1982 May;76(1):3-31. doi: 10.1111/j.1476-5381.1982.tb09186.x.
6
The prostanoids in hemostasis and thrombosis: a review.前列腺素类物质在止血和血栓形成中的作用：综述
Am J Pathol. 1980 Jun;99(3):743-804.
7
Prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation of rabbit platelets.前列腺素内过氧化物、血栓素A2和二磷酸腺苷在胶原诱导的兔血小板聚集中的作用
Br J Pharmacol. 1982 Apr;75(4):623-31. doi: 10.1111/j.1476-5381.1982.tb09183.x.
8
Abnormal platelet response to thromboxane A2.血小板对血栓素A2的异常反应。
J Clin Invest. 1981 Jun;67(6):1801-4. doi: 10.1172/jci110221.
9
Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins.前列腺素内过氧化物。关于前列腺素作用方式和释放的新概念。
Proc Natl Acad Sci U S A. 1974 Oct;71(10):3824-8. doi: 10.1073/pnas.71.10.3824.
10
Blood platelets and the inflammatory process.血小板与炎症过程。
Agents Actions. 1974 Oct;4(4):233-40. doi: 10.1007/BF01965226.

本文引用的文献

1
RELEASE OF A PLATELET-AGGREGATING SUBSTANCE (ADENOSINE DIPHOSPHATE) FROM RABBIT BLOOD PLATELETS INDUCED BY SALINE "EXTRACT" OF TENDONS.肌腱盐水“提取物”诱导兔血小板释放血小板聚集物质（二磷酸腺苷）
Thromb Diath Haemorrh. 1963 Jul 15;143:264-78.
2
The effect of salicylates on the hemostatic properties of platelets in man.水杨酸盐对人体血小板止血特性的影响。
J Clin Invest. 1968 Sep;47(9):2169-80. doi: 10.1172/JCI105903.
3
The release of nucleotides, 5-hydroxytryptamine and enzymes from human blood platelets during aggregation.人血小板聚集过程中核苷酸、5-羟色胺及酶的释放。
J Physiol. 1968 Apr;195(3):715-29. doi: 10.1113/jphysiol.1968.sp008484.
4
Formation and release of prostaglandins by platelets in response to thrombin.血小板对凝血酶作出反应时前列腺素的形成与释放。
Br J Pharmacol. 1970 Nov;40(3):545P-546P.
5
Mechanism of prostaglandin biosynthesis. 18 O2 studies on PGF 1 alpha.前列腺素生物合成机制。关于前列腺素F1α的18O2研究。
Ann N Y Acad Sci. 1971 Apr 30;180:126-37. doi: 10.1111/j.1749-6632.1971.tb53192.x.
6
Prostaglandin production by mouse fibrosarcoma cells in culture: inhibition by indomethacin and aspirin.培养的小鼠纤维肉瘤细胞中前列腺素的产生：吲哚美辛和阿司匹林的抑制作用
Biochem Biophys Res Commun. 1972 May 26;47(4):888-96. doi: 10.1016/0006-291x(72)90576-1.
7
Relationship between chemical structure and platelet-aggregation activity of prostaglandins.前列腺素的化学结构与血小板聚集活性之间的关系。
Biochim Biophys Acta. 1969 Oct 28;187(3):285-92. doi: 10.1016/0005-2760(69)90001-0.
8
Extraction of prostaglandins from human blood.从人体血液中提取前列腺素。
Nature. 1971 Oct 1;233(5318):336-7. doi: 10.1038/233336b0.
9
A new potential mediator of arterial thrombosis whose biosynthesis is inhibited by aspirin.一种新的动脉血栓形成潜在介质，其生物合成受阿司匹林抑制。
Prostaglandins. 1973 Jul;4(1):127-30. doi: 10.1016/0090-6980(73)90062-2.
10
Formation of prostaglandins during the aggregation of human blood platelets.人血小板聚集过程中前列腺素的形成。
J Clin Invest. 1973 Apr;52(4):965-9. doi: 10.1172/JCI107262.

前列腺素生物合成中一种中间体的形成及其与血小板释放反应的关联。

Formation of an intermediate in prostaglandin biosynthesis and its association with the platelet release reaction.

作者信息

Smith J B, Ingerman C, Kocsis J J, Silver M J

出版信息

J Clin Invest. 1974 May;53(5):1468-72. doi: 10.1172/JCI107695.

DOI:10.1172/JCI107695
PMID:4825236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC302635/
Abstract

A compound that could be converted to prostaglandin F(2alpha) by mild chemical reduction was formed by human platelets in response to arachidonic acid, collagen, or L-epinephrine. It was present in maximal amounts at about 1 min after addition of arachidonic acid or collagen to platelet-rich plasma. Its initial formation appeared to precede platelet aggregation by these agents and was closely correlated with the release of adenine nucleotides and radioactive 5-hydroxytryptamine from platelets. Moreover, the compound was itself found outside the platelets. This compound is probably an endoperoxide intermediate in prostaglandin biosynthesis and may be a trigger for the platelet release reaction.

摘要

一种可通过温和化学还原转化为前列腺素F(2α)的化合物，由人血小板在花生四烯酸、胶原或L-肾上腺素作用下形成。在向富含血小板的血浆中添加花生四烯酸或胶原后约1分钟时，其含量达到最高。这些物质最初形成似乎先于血小板聚集，并且与血小板中腺嘌呤核苷酸和放射性5-羟色胺的释放密切相关。此外，该化合物本身也存在于血小板外。这种化合物可能是前列腺素生物合成中的一种内过氧化物中间体，可能是血小板释放反应的触发因素。