Departments of Gastrointestinal Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Departments of Gastrointestinal Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. Email:
Asia Pac J Clin Nutr. 2020;29(3):469-475. doi: 10.6133/apjcn.202009_29(3).0004.
We assessed the effect of enteral ecoimmunonutrition (enteral nutrition involving probiotics and immune nutrients) on gastric cancer in the postoperative period.
In total, 60 patients with gastric cancer were randomized into an enteral ecoimmunonutrition group or an enteral nutrition group. Information on postoperative complications; hospitalization length; time to first bowel movement and first flatus; and differences between preoperative and postoperative nutritional status, inflammatory reactions, and immune function was collected.
No significant between-group differences in nutritional status and complications were observed. C-reactive protein concentrations were lower in the enteral ecoimmunonutrition group than in the enteral nutrition group on postoperative day 7 (p<0.001) and CD4+ concentrations were significantly higher (p=0.01). The enteral ecoimmunonutrition group had a significantly shorter time to first flatus than the enteral nutrition group (p=0.03).
Early postoperative enteral ecoimmunonutrition significantly improved immune function, reduced inflammatory responses, and promoted intestinal function recovery in patients with gastric cancer undergoing gastrectomy.
我们评估了肠内生态免疫营养（涉及益生菌和免疫营养素的肠内营养）对胃癌术后的影响。
共纳入 60 例胃癌患者，随机分为肠内生态免疫营养组或肠内营养组。收集术后并发症、住院时间、首次排气和排便时间以及术前和术后营养状况、炎症反应和免疫功能差异的信息。
两组间营养状况和并发症无显著差异。术后第 7 天，肠内生态免疫营养组 C 反应蛋白浓度低于肠内营养组（p<0.001），CD4+浓度显著升高（p=0.01）。肠内生态免疫营养组首次排气时间明显短于肠内营养组（p=0.03）。
胃癌患者术后早期给予肠内生态免疫营养可显著改善免疫功能，减轻炎症反应，促进肠道功能恢复。
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